The pharmacological potential and possible molecular mechanisms of action of Inonotus obliquus from preclinical studies

• Published in: Phytotherapy research 2019-08, Vol.33 (8), p.1966-1980
• Main Authors: Duru, Kingsley C., Kovaleva, Elena G., Danilova, Irina G., Bijl, Pieter
• Format: Article
• Language: English
• Subjects: anticancer; Anticancer properties; antiviral; Antiviral activity; Chemical analysis; Chemical compounds; Diabetes; Diabetes mellitus; Diabetes mellitus (non-insulin dependent); Functional foods & nutraceuticals; Hypoglycemia; Immune system; immunostimulatory; inflammation; Inonotus obliquus; Insulin; Medical treatment; Molecular modelling; Mushrooms; Organic chemistry; Pathogenesis; Pharmacology; Phenolic compounds; Phenols; Reactive oxygen species; Triterpenoids; Tumors; type 2 diabetes
• ISSN: 0951-418X; 1099-1573
• DOI: 10.1002/ptr.6384

The use of mushrooms as functional foods and in the treatment of diseases has a long history. Inonotus obliquus is a mushroom belonging to the Hymenochaetaceae family and has possible anticancer, antiviral, and hypoglycemic properties. Chemical analysis of this mushroom has allowed the identification of various constituents such as melanins, phenolic compounds, and lanostane‐type triterpenoids. A plethora of findings have highlighted the potential molecular mechanisms of actions of this mushroom such as its ability to scavenge reactive oxygen species, inhibit the growth of tumors, decrease inflammation and insulin resistance in type 2 diabetes, and stimulate the immune system. This review summarizes the relevant findings with reference to the therapeutic potential of this mushroom in countering the progression of cancers, diabetes mellitus, and antiviral activities, while highlighting its possible molecular mechanisms of action. The possible role of this mushroom as a therapeutic agent in addressing the pathogenesis of diabetes and cancer has also been suggested. Chemical analysis of Inonotus obliquus has shown that this mushroom contains numerous bioactive compounds. A plethora of findings from the literature search supported the pharmacological potentials of Inonotus obliquus as an antidiabetic, antitumor, anti‐inflammatory, antiviral, and immunostimulating agent. Limitations such as the lack of standard extraction techniques and little to no clinical trials of the potential health benefits of this mushroom in human studies were also highlighted. The possible efficient use of this mushroom in preclinical studies was also suggested.