Detection of preoperative chemoradiotherapy sensitivity molecular characteristics of rectal cancer by transcriptome second generation sequencing

To detect the preoperative chemoradiotherapy sensitivity molecular characteristics of rectal cancer by transcriptome second generation sequencing. The clinicopathological data of 30 patients with locally advanced rectal cancer were collected prospectively, including 9 indicators (general conditions,...

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Bibliographic Details
Published in:Beijing da xue xue bao. Journal of Peking University. Yi xue ban 2019-06, Vol.51 (3), p.542-547
Main Authors: Zhang, W, Ye, Y J, Ren, X W, Huang, J, Shen, Z L
Format: Article
Language:Chinese
Subjects:
Chemoradiotherapy
Exosome Multienzyme Ribonuclease Complex
Humans
Neoadjuvant Therapy
Neoplasm Staging
Rectal Neoplasms - therapy
Retrospective Studies
RNA-Binding Proteins
Transcriptome
Treatment Outcome
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Summary:To detect the preoperative chemoradiotherapy sensitivity molecular characteristics of rectal cancer by transcriptome second generation sequencing. The clinicopathological data of 30 patients with locally advanced rectal cancer were collected prospectively, including 9 indicators (general conditions, imaging data before radiotherapy and chemotherapy, pathological data of biopsy before radiotherapy and chemotherapy, and tumor differentiation degree, etc.), in order to analyze the correlation between them and tumor regression grading (TRG) after radiotherapy and chemotherapy for rectal cancer. At the same time, frozen specimens of colonoscopy biopsy before neoadjuvant therapy were collected from these 30 patients, and transcriptome second-generation sequencing was performed for bioinformatics analysis to screen out the genes that might drive the radio chemotherapy sensitivity of rectal cancer. Among the 30 patients with rectal cancer, 9 had complete pathological remission, 12 had partial remission, and 9 had poo
ISSN:1671-167X
DOI:10.19723/j.issn.1671-167X.2019.03.025