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Detection of preoperative chemoradiotherapy sensitivity molecular characteristics of rectal cancer by transcriptome second generation sequencing

To detect the preoperative chemoradiotherapy sensitivity molecular characteristics of rectal cancer by transcriptome second generation sequencing. The clinicopathological data of 30 patients with locally advanced rectal cancer were collected prospectively, including 9 indicators (general conditions,...

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Published in:	Beijing da xue xue bao. Journal of Peking University. Yi xue ban 2019-06, Vol.51 (3), p.542-547
Main Authors:	Zhang, W, Ye, Y J, Ren, X W, Huang, J, Shen, Z L
Format:	Article
Language:	Chinese
Subjects:	Chemoradiotherapy Exosome Multienzyme Ribonuclease Complex Humans Neoadjuvant Therapy Neoplasm Staging Rectal Neoplasms - therapy Retrospective Studies RNA-Binding Proteins Transcriptome Treatment Outcome
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container_title	Beijing da xue xue bao. Journal of Peking University. Yi xue ban
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creator	Zhang, W Ye, Y J Ren, X W Huang, J Shen, Z L
description	To detect the preoperative chemoradiotherapy sensitivity molecular characteristics of rectal cancer by transcriptome second generation sequencing. The clinicopathological data of 30 patients with locally advanced rectal cancer were collected prospectively, including 9 indicators (general conditions, imaging data before radiotherapy and chemotherapy, pathological data of biopsy before radiotherapy and chemotherapy, and tumor differentiation degree, etc.), in order to analyze the correlation between them and tumor regression grading (TRG) after radiotherapy and chemotherapy for rectal cancer. At the same time, frozen specimens of colonoscopy biopsy before neoadjuvant therapy were collected from these 30 patients, and transcriptome second-generation sequencing was performed for bioinformatics analysis to screen out the genes that might drive the radio chemotherapy sensitivity of rectal cancer. Among the 30 patients with rectal cancer, 9 had complete pathological remission, 12 had partial remission, and 9 had poo
doi_str_mv	10.19723/j.issn.1671-167X.2019.03.025
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subjects	Chemoradiotherapy Exosome Multienzyme Ribonuclease Complex Humans Neoadjuvant Therapy Neoplasm Staging Rectal Neoplasms - therapy Retrospective Studies RNA-Binding Proteins Transcriptome Treatment Outcome
title	Detection of preoperative chemoradiotherapy sensitivity molecular characteristics of rectal cancer by transcriptome second generation sequencing
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