Stabilizing excipients for engineered clopidogrel bisulfate procubosome derived in situ cubosomes for enhanced intestinal dissolution: Stability and bioavailability considerations

Clopidogrel bisulfate (CB) is a golden antiplatelet treatment, yet its benefits are limited by its low bioavailability (

Saved in:
Bibliographic Details
Published in:European journal of pharmaceutical sciences 2019-08, Vol.136, p.104954-104954, Article 104954
Main Authors: El-Laithy, Hanan M., Badawi, Alia, Abdelmalak, Nevine Shawky, Elsayyad, Nihal Mohamed Elmahdy
Format: Article
Language:English
Subjects:
Administration, Oral
Animals
Bioavailability
Biological Availability
Clopidogrel - chemistry
Clopidogrel - metabolism
Clopidogrel bisulfate
Cubosomes
Drug Delivery Systems - methods
Excipients - chemistry
Freeze drying
Freeze Drying - methods
Intestines - drug effects
Male
Nanoparticles - chemistry
Particle Size
Poloxamer - chemistry
Procubosomes
Rabbits
Solubility
Stability
Stabilizing excipients
Tablets - chemistry
Tablets - metabolism
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Clopidogrel bisulfate (CB) is a golden antiplatelet treatment, yet its benefits are limited by its low bioavailability (
ISSN:0928-0987
1879-0720
DOI:10.1016/j.ejps.2019.06.008