Evidence of increased hypoxia signaling in fetal liver from maternal nutrient restriction in mice

Background Intrauterine growth restriction (IUGR) is a pregnancy condition where fetal growth is reduced, and offspring from IUGR pregnancies are at increased risk for type II diabetes as adults. The liver is susceptible to fetal undernutrition experienced by IUGR infants and animal models of growth...

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Published in:Pediatric research 2020-02, Vol.87 (3), p.450-455
Main Authors: Radford, Bethany N., Han, Victor K. M.
Format: Article
Language:English
Subjects:
Adaptation, Physiological
Animal Nutritional Physiological Phenomena
Animals
Animals, Newborn
Basic Science Article
Disease Models, Animal
Female
Fetal Growth Retardation - genetics
Fetal Growth Retardation - metabolism
Fetal Growth Retardation - physiopathology
Fetal Hypoxia - genetics
Fetal Hypoxia - metabolism
Fetal Hypoxia - physiopathology
Gene Expression Regulation, Developmental
Gestational Age
Hypoxia
Liver
Liver - growth & development
Liver - metabolism
Male
Maternal Nutritional Physiological Phenomena
Medicine
Medicine & Public Health
Mice
Nutritional Status
Pediatric Surgery
Pediatrics
Pregnancy
Prenatal Exposure Delayed Effects
Signal Transduction - genetics
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Summary:Background Intrauterine growth restriction (IUGR) is a pregnancy condition where fetal growth is reduced, and offspring from IUGR pregnancies are at increased risk for type II diabetes as adults. The liver is susceptible to fetal undernutrition experienced by IUGR infants and animal models of growth restriction. This study aimed to examine hepatic expression changes in a maternal nutrient restriction (MNR) mouse model of IUGR to understand fetal adaptations that influence adult metabolism. Methods Liver samples of male offspring from MNR (70% of ad libitum starting at E6.5) or control pregnancies were obtained at E18.5 and differential expression was assessed by RNAseq and western blots. Results Forty-nine differentially expressed (FDR 
ISSN:0031-3998
1530-0447
DOI:10.1038/s41390-019-0447-z