Lifespan normative data on rates of brain volume changes

We provide here normative values of yearly percentage brain volume change (PBVC/y) as obtained with Structural Imaging Evaluation, using Normalization, of Atrophy, a widely used open-source software, developing a PBVC/y calculator for assessing the deviation from the expected PBVC/y in patients with...

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Bibliographic Details
Published in:Neurobiology of aging 2019-09, Vol.81, p.30-37
Main Authors: Battaglini, Marco, Gentile, Giordano, Luchetti, Ludovico, Giorgio, Antonio, Vrenken, Hugo, Barkhof, Frederik, Cover, Keith S., Bakshi, Rohit, Chu, Renxin, Sormani, Maria Pia, Enzinger, Christian, Ropele, Stefan, Ciccarelli, Olga, Wheeler-Kingshott, Claudia, Yiannakas, Marios, Filippi, Massimo, Rocca, Maria Assunta, Preziosa, Paolo, Gallo, Antonio, Bisecco, Alvino, Palace, Jacqueline, Kong, Yazhuo, Horakova, Dana, Vaneckova, Manuela, Gasperini, Claudio, Ruggieri, Serena, De Stefano, Nicola
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Aged, 80 and over
Aging
Aging - pathology
Atrophy
Brain - diagnostic imaging
Brain - pathology
Brain volume
Diffusion Magnetic Resonance Imaging
Female
Humans
Imaging, Three-Dimensional
Longevity
Male
Middle Aged
MRI
Multicenter Studies as Topic
Normative data
Organ Size
Retrospective Studies
Young Adult
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Summary:We provide here normative values of yearly percentage brain volume change (PBVC/y) as obtained with Structural Imaging Evaluation, using Normalization, of Atrophy, a widely used open-source software, developing a PBVC/y calculator for assessing the deviation from the expected PBVC/y in patients with neurological disorders. We assessed multicenter (34 centers, 11 acquisition protocols) magnetic resonance imaging data of 720 healthy participants covering the whole adult lifespan (16–90 years). Data of 421 participants with a follow-up > 6 months were used to obtain the normative values for PBVC/y and data of 392 participants with a follow-up
ISSN:0197-4580
1558-1497
DOI:10.1016/j.neurobiolaging.2019.05.010