Long-term Prognostic Impact of Chromosome Abnormalities in Clear Cell Renal Cell Carcinoma

Clear cell renal cell carcinoma (ccRCC) shows variable chromosomal abnormalities. The aim of this study was to assess the prognostic role of ccRCC chromosomal abnormalities in a single-center cohort with an extended follow-up. A systematic cytogenetic analysis was performed in 283 consecutive surgic...

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Bibliographic Details
Published in:Anticancer research 2019-06, Vol.39 (6), p.2757-2765
Main Authors: Palumbo, Carlotta, Furlan, Maria, Balzarini, Piera, Zanotelli, Tiziano, Cozzoli, Alberto, Veccia, Alessandro, Francavilla, Simone, Zamboni, Stefania, Tardanico, Regina, Simeone, Claudio, Antonelli, Alessandro
Format: Article
Language:English
Subjects:
Abnormalities
Aged
Cancer
Carcinoma, Renal Cell - genetics
Carcinoma, Renal Cell - mortality
Carcinoma, Renal Cell - surgery
Chromosome 18
Chromosome 3
Chromosome Aberrations
Chromosome Deletion
Chromosomes
Chromosomes, Human - genetics
Clear cell-type renal cell carcinoma
Clonal deletion
Cytogenetics
Female
Genetic analysis
Health risk assessment
Humans
Kaplan-Meier Estimate
Kidney cancer
Kidney Neoplasms - genetics
Kidney Neoplasms - mortality
Kidney Neoplasms - surgery
Male
Middle Aged
Mutagenesis, Insertional
Prognosis
Proportional Hazards Models
Regression analysis
Retrospective Studies
Treatment Outcome
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Summary:Clear cell renal cell carcinoma (ccRCC) shows variable chromosomal abnormalities. The aim of this study was to assess the prognostic role of ccRCC chromosomal abnormalities in a single-center cohort with an extended follow-up. A systematic cytogenetic analysis was performed in 283 consecutive surgically-treated patients for renal masses between 1997 and 2002. Kaplan-Meier and multivariable Cox regression (MCR) models were used to calculate cancer specific survival (CSS). Among 174 ccRCC patients, the most common abnormality was deletion in chromosome 3 (54.6%). At a median follow-up of 119 months, 38 patients (21.8%) died from RCC. At MCR models, worse CSS was independently predicted by deletions in chromosomes 2, 19, 20 or 22 and insertions in chromosome 18. Specific ccRCC chromosomal abnormalities are independently associated with worse CSS. Cytogenetic evaluation may direct further genetic analysis for personalized prognostic stratification.
ISSN:0250-7005
1791-7530
DOI:10.21873/anticanres.13402