Phosphorylation of STAT1 serine 727 enhances platinum resistance in uterine serous carcinoma

Uterine serous carcinoma (USC) is a highly aggressive histological subtype of endometrial cancers harboring highly metastatic and chemoresistant features. Our previous study showed that STAT1 is highly expressed in USC and acts as a key molecule that is positively correlated with tumor progression,...

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Bibliographic Details
Published in:International journal of cancer 2019-09, Vol.145 (6), p.1635-1647
Main Authors: Zeng, Xiang, Baba, Tsukasa, Hamanishi, Junzo, Matsumura, Noriomi, Kharma, Budiman, Mise, Yuka, Abiko, Kaoru, Yamaguchi, Ken, Horikawa, Naoki, Hunstman, David G., Mulati, Kumuluzi, Kitamura, Sachiko, Taki, Mana, Murakami, Ryusuke, Hosoe, Yuko, Mandai, Masaki
Format: Article
Language:English
Subjects:
Accumulation
Animals
Antineoplastic Agents - pharmacology
Antineoplastic Agents - therapeutic use
Apoptosis
Apoptosis - drug effects
Cancer
Casein
casein kinase 2
Casein kinase II
Cell Line, Tumor
Cell Proliferation - drug effects
Chemotherapy, Adjuvant
Cisplatin
Cisplatin - pharmacology
Cisplatin - therapeutic use
copper transport protein
Cystadenocarcinoma, Serous - drug therapy
Cystadenocarcinoma, Serous - metabolism
Cystadenocarcinoma, Serous - pathology
Cytotoxicity
Drug Resistance, Neoplasm
Endometrial cancer
Endometrium
Female
Heterografts
Humans
Intracellular
Medical research
Metastases
Mice, Inbred NOD
Mice, Nude
Mice, SCID
Nuclei (cytology)
Phosphorylation
Platinum
pSTAT1‐serine (Ser727)
Serine
Serine - metabolism
STAT1
Stat1 protein
STAT1 Transcription Factor - chemistry
STAT1 Transcription Factor - metabolism
Tyrosine
Uterine Neoplasms - drug therapy
Uterine Neoplasms - metabolism
Uterine Neoplasms - pathology
uterine serous carcinoma
Uterus
Xenografts
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Summary:Uterine serous carcinoma (USC) is a highly aggressive histological subtype of endometrial cancers harboring highly metastatic and chemoresistant features. Our previous study showed that STAT1 is highly expressed in USC and acts as a key molecule that is positively correlated with tumor progression, but it remains unclear whether STAT1 is relevant to the malicious chemorefractory nature of USC. In the present study, we investigated the regulatory role of STAT1 toward platinum‐cytotoxicity in USC. STAT1 suppression sensitized USC cells to increase cisplatin‐mediated apoptosis (p 
ISSN:0020-7136
1097-0215
DOI:10.1002/ijc.32501