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Omega‐3‐rich Isochrysis sp. biomass enhances brain docosahexaenoic acid levels and improves serum lipid profile and antioxidant status in Wistar rats

BACKGROUND Isochrysis sp. is a marine microalga, rich in eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). The potential use of its biomass as an alternative source of polyunsaturated fatty acids (PUFAs) has not been studied in animal models. Male albino Wistar rats were divided into three...

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Published in:Journal of the science of food and agriculture 2019-10, Vol.99 (13), p.6066-6075
Main Authors: Balakrishnan, Jeyakumar, Dhavamani, Sugasini, Sadasivam, Selvam Govindan, Arumugam, Muthu, Vellaikumar, Sampathrajan, Ramalingam, Jagadeesan, Shanmugam, Kathiresan
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Language:English
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Summary:BACKGROUND Isochrysis sp. is a marine microalga, rich in eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). The potential use of its biomass as an alternative source of polyunsaturated fatty acids (PUFAs) has not been studied in animal models. Male albino Wistar rats were divided into three groups and treated for 28 days. The rats were fed with (1) standard chow (control group), (2) microalgal biomass rich in EPA and DHA along with standard chow (microalga group), and (3) fish oil that contains equivalent amounts of EPA and DHA along with standard chow (fish oil group). After intervention, biochemical indices, histopathological indices, relative mRNA expression of PUFA genes, antioxidant genes, inflammatory markers, and the fatty acid profile of major tissues were studied. RESULTS Animals treated with microalgal biomass showed significantly increased serum HDL levels (P 
ISSN:0022-5142
1097-0010
DOI:10.1002/jsfa.9884