Primary central nervous system lymphoma: A curable disease

Primary central nervous system lymphoma is a rare subtype of non‐Hodgkin lymphoma that is confined to the brain, leptomeninges, or the eye and is associated with a relatively poor prognosis compared to other extranodal diffuse large B‐cell lymphomas. However, methotrexate‐based induction chemotherap...

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Bibliographic Details
Published in:Hematological oncology 2019-06, Vol.37 (S1), p.15-18
Main Author: Batchelor, Tracy T.
Format: Article
Language:English
Subjects:
Autografts
Brain
Cell activation
Central nervous system
Chemotherapy
Lymphocytes B
Lymphoma
Medical prognosis
Methotrexate
Nervous system
Neurotoxicity
Non-Hodgkin's lymphoma
Stem cells
Transplantation
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Summary:Primary central nervous system lymphoma is a rare subtype of non‐Hodgkin lymphoma that is confined to the brain, leptomeninges, or the eye and is associated with a relatively poor prognosis compared to other extranodal diffuse large B‐cell lymphomas. However, methotrexate‐based induction chemotherapy followed by consolidative chemotherapy or high‐dose therapy and autologous stem cell transplantation is associated with improved survival and reduced neurotoxicity. Aberrant activation of B‐cell receptor signaling and activation of nuclear factor kappa beta is a frequent genetic alteration and offers opportunities for targeted therapies in this lymphoma subtype.
ISSN:0278-0232
1099-1069
DOI:10.1002/hon.2598