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Association of elevated serum triglyceride levels with a more severe course of acute pancreatitis: Cohort analysis of 1457 patients
Previous publications have reported an association between hypertriglyceridemia (HTG) and severity of acute pancreatitis, but this relationship remains somewhat controversial. To evaluate the outcome of acute pancreatitis according to serum triglyceride levels on admission. Retrospective analysis of...
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| Published in: | Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] 2019-07, Vol.19 (5), p.623-629 |
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| cites | cdi_FETCH-LOGICAL-c381t-ed2bd65b080a2b5c924fdd764415112497a79548dd4b03612834ec440c77e1283 |
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| container_title | Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] |
| container_volume | 19 |
| creator | Pascual, Isabel Sanahuja, Ana García, Natalia Vázquez, Paola Moreno, Oswaldo Tosca, Joan Peña, Andrés Garayoa, Ana Lluch, Paloma Mora, Francisco |
| description | Previous publications have reported an association between hypertriglyceridemia (HTG) and severity of acute pancreatitis, but this relationship remains somewhat controversial.
To evaluate the outcome of acute pancreatitis according to serum triglyceride levels on admission.
Retrospective analysis of prospectively collected data, which included all consecutive cases of acute pancreatitis admitted to a tertiary hospital (January 2002–December 2014). Acute pancreatitis patients were classified into 3 groups based on serum triglyceride levels (mg/dl) measured within 48 h from admission: normal triglycerides-mild HTG ( |
| doi_str_mv | 10.1016/j.pan.2019.06.006 |
| format | article |
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To evaluate the outcome of acute pancreatitis according to serum triglyceride levels on admission.
Retrospective analysis of prospectively collected data, which included all consecutive cases of acute pancreatitis admitted to a tertiary hospital (January 2002–December 2014). Acute pancreatitis patients were classified into 3 groups based on serum triglyceride levels (mg/dl) measured within 48 h from admission: normal triglycerides-mild HTG (<200); moderate HTG (200–749); severe HTG (≥750). Primary outcomes were the difference in organ failure, pancreatic necrosis, acute peripancreatic collections and mortality among the three groups.
A total of 1,457 cases were included: 1,335 with normal-mild HTG, 77 with moderate HTG and 45 with severe HTG. The rates of organ failure (11.2% in normal-mild HTG group, 15.6% in moderate HTG and 20.0% in severe HTG), persistent multiple organ failure (2.5% vs. 5.2% vs. 6.7%), pancreatic necrosis (9.2% vs. 14.3% vs. 26.7%) and acute collections (21.6% vs. 40.3% vs. 55.6%) increased significantly with hypertriglyceridemia severity grades. On multivariate analysis, triglycerides as a quantitative variable, evaluated in increments of 100 mg/dl, was independently associated with organ failure, pancreatic necrosis, acute collections and mortality (p < 0.05).
Elevated serum triglyceride levels are independently associated with a more severe course of pancreatitis. It must be highlighted the elevated frequency of local complications in patients with HTG that increases proportionally and significantly with HTG severity grades.</description><identifier>ISSN: 1424-3903</identifier><identifier>EISSN: 1424-3911</identifier><identifier>DOI: 10.1016/j.pan.2019.06.006</identifier><identifier>PMID: 31229460</identifier><language>eng</language><publisher>Switzerland: Elsevier B.V</publisher><subject>Acute Disease ; Acute pancreatitis ; Adolescent ; Adult ; Age ; Aged ; Aged, 80 and over ; Body mass index ; Cohort analysis ; Cohort Studies ; Comorbidity ; Data collection ; Diabetes ; Etiology ; Failure ; Female ; Humans ; Hypertriglyceridemia ; Hypertriglyceridemia - blood ; Hypertriglyceridemia - complications ; Hypertriglyceridemia - mortality ; Hypertriglyceridemic pancreatitis ; Male ; Metabolism ; Middle Aged ; Mortality ; Multiple Organ Failure - etiology ; Multiple Organ Failure - mortality ; Multivariate analysis ; Necrosis ; Organ failure ; Pancreas ; Pancreas - pathology ; Pancreatitis ; Pancreatitis - blood ; Pancreatitis - complications ; Pancreatitis - mortality ; Pancreatitis, Acute Necrotizing - blood ; Patients ; Prognosis ; Retrospective Studies ; Risk Factors ; Severity ; Treatment Outcome ; Triglycerides ; Triglycerides - blood ; Variables ; Young Adult</subject><ispartof>Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.], 2019-07, Vol.19 (5), p.623-629</ispartof><rights>2019 IAP and EPC</rights><rights>Copyright © 2019 IAP and EPC. Published by Elsevier B.V. All rights reserved.</rights><rights>2019. IAP and EPC</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c381t-ed2bd65b080a2b5c924fdd764415112497a79548dd4b03612834ec440c77e1283</citedby><cites>FETCH-LOGICAL-c381t-ed2bd65b080a2b5c924fdd764415112497a79548dd4b03612834ec440c77e1283</cites><orcidid>0000-0002-1628-1914 ; 0000-0001-5008-5821</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,27925,27926</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31229460$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pascual, Isabel</creatorcontrib><creatorcontrib>Sanahuja, Ana</creatorcontrib><creatorcontrib>García, Natalia</creatorcontrib><creatorcontrib>Vázquez, Paola</creatorcontrib><creatorcontrib>Moreno, Oswaldo</creatorcontrib><creatorcontrib>Tosca, Joan</creatorcontrib><creatorcontrib>Peña, Andrés</creatorcontrib><creatorcontrib>Garayoa, Ana</creatorcontrib><creatorcontrib>Lluch, Paloma</creatorcontrib><creatorcontrib>Mora, Francisco</creatorcontrib><title>Association of elevated serum triglyceride levels with a more severe course of acute pancreatitis: Cohort analysis of 1457 patients</title><title>Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.]</title><addtitle>Pancreatology</addtitle><description>Previous publications have reported an association between hypertriglyceridemia (HTG) and severity of acute pancreatitis, but this relationship remains somewhat controversial.
To evaluate the outcome of acute pancreatitis according to serum triglyceride levels on admission.
Retrospective analysis of prospectively collected data, which included all consecutive cases of acute pancreatitis admitted to a tertiary hospital (January 2002–December 2014). Acute pancreatitis patients were classified into 3 groups based on serum triglyceride levels (mg/dl) measured within 48 h from admission: normal triglycerides-mild HTG (<200); moderate HTG (200–749); severe HTG (≥750). Primary outcomes were the difference in organ failure, pancreatic necrosis, acute peripancreatic collections and mortality among the three groups.
A total of 1,457 cases were included: 1,335 with normal-mild HTG, 77 with moderate HTG and 45 with severe HTG. The rates of organ failure (11.2% in normal-mild HTG group, 15.6% in moderate HTG and 20.0% in severe HTG), persistent multiple organ failure (2.5% vs. 5.2% vs. 6.7%), pancreatic necrosis (9.2% vs. 14.3% vs. 26.7%) and acute collections (21.6% vs. 40.3% vs. 55.6%) increased significantly with hypertriglyceridemia severity grades. On multivariate analysis, triglycerides as a quantitative variable, evaluated in increments of 100 mg/dl, was independently associated with organ failure, pancreatic necrosis, acute collections and mortality (p < 0.05).
Elevated serum triglyceride levels are independently associated with a more severe course of pancreatitis. It must be highlighted the elevated frequency of local complications in patients with HTG that increases proportionally and significantly with HTG severity grades.</description><subject>Acute Disease</subject><subject>Acute pancreatitis</subject><subject>Adolescent</subject><subject>Adult</subject><subject>Age</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Body mass index</subject><subject>Cohort analysis</subject><subject>Cohort Studies</subject><subject>Comorbidity</subject><subject>Data collection</subject><subject>Diabetes</subject><subject>Etiology</subject><subject>Failure</subject><subject>Female</subject><subject>Humans</subject><subject>Hypertriglyceridemia</subject><subject>Hypertriglyceridemia - blood</subject><subject>Hypertriglyceridemia - complications</subject><subject>Hypertriglyceridemia - mortality</subject><subject>Hypertriglyceridemic pancreatitis</subject><subject>Male</subject><subject>Metabolism</subject><subject>Middle Aged</subject><subject>Mortality</subject><subject>Multiple Organ Failure - etiology</subject><subject>Multiple Organ Failure - mortality</subject><subject>Multivariate analysis</subject><subject>Necrosis</subject><subject>Organ failure</subject><subject>Pancreas</subject><subject>Pancreas - pathology</subject><subject>Pancreatitis</subject><subject>Pancreatitis - blood</subject><subject>Pancreatitis - complications</subject><subject>Pancreatitis - mortality</subject><subject>Pancreatitis, Acute Necrotizing - blood</subject><subject>Patients</subject><subject>Prognosis</subject><subject>Retrospective Studies</subject><subject>Risk Factors</subject><subject>Severity</subject><subject>Treatment Outcome</subject><subject>Triglycerides</subject><subject>Triglycerides - blood</subject><subject>Variables</subject><subject>Young Adult</subject><issn>1424-3903</issn><issn>1424-3911</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNp9kUFv1DAQhS0EoqXwA7ggS1y4bPA4jpPAqVpBQarEBc6WY89Sr5J48TiL9swfx9GWHnrgNLb8vSfPe4y9BlGBAP1-Xx3sXEkBfSV0JYR-wi5BSbWpe4CnD2dRX7AXRHshpATon7OLGqTslRaX7M81UXTB5hBnHnccRzzajJ4TpmXiOYWf48lhCh55ecKR-O-Q77jlU0xYqCOW4eKSCFe9dUtGXr7lEhbTHOgD38a7mDK3sx1PFGjFQDVtoXLAOdNL9mxnR8JX9_OK_fj86fv2y-b2283X7fXtxtUd5A16OXjdDKITVg6N66Xaed9qpaABkKpvbds3qvNeDaLWILtaoVNKuLbF9XbF3p19Dyn-WpCymQI5HEc7Y1zISKm0rBvRqIK-fYTuy4plgZXSre6aupeFgjPlUiRKuDOHFCabTgaEWRsye1OiMGtDRmhTGiqaN_fOyzChf1D8q6QAH89AyRqPAZMhV2Jy6ENCl42P4T_2fwFEsqDa</recordid><startdate>201907</startdate><enddate>201907</enddate><creator>Pascual, Isabel</creator><creator>Sanahuja, Ana</creator><creator>García, Natalia</creator><creator>Vázquez, Paola</creator><creator>Moreno, Oswaldo</creator><creator>Tosca, Joan</creator><creator>Peña, Andrés</creator><creator>Garayoa, Ana</creator><creator>Lluch, Paloma</creator><creator>Mora, Francisco</creator><general>Elsevier B.V</general><general>Elsevier Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-1628-1914</orcidid><orcidid>https://orcid.org/0000-0001-5008-5821</orcidid></search><sort><creationdate>201907</creationdate><title>Association of elevated serum triglyceride levels with a more severe course of acute pancreatitis: Cohort analysis of 1457 patients</title><author>Pascual, Isabel ; Sanahuja, Ana ; García, Natalia ; Vázquez, Paola ; Moreno, Oswaldo ; Tosca, Joan ; Peña, Andrés ; Garayoa, Ana ; Lluch, Paloma ; Mora, Francisco</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c381t-ed2bd65b080a2b5c924fdd764415112497a79548dd4b03612834ec440c77e1283</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Acute Disease</topic><topic>Acute pancreatitis</topic><topic>Adolescent</topic><topic>Adult</topic><topic>Age</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Body mass index</topic><topic>Cohort analysis</topic><topic>Cohort Studies</topic><topic>Comorbidity</topic><topic>Data collection</topic><topic>Diabetes</topic><topic>Etiology</topic><topic>Failure</topic><topic>Female</topic><topic>Humans</topic><topic>Hypertriglyceridemia</topic><topic>Hypertriglyceridemia - blood</topic><topic>Hypertriglyceridemia - complications</topic><topic>Hypertriglyceridemia - mortality</topic><topic>Hypertriglyceridemic pancreatitis</topic><topic>Male</topic><topic>Metabolism</topic><topic>Middle Aged</topic><topic>Mortality</topic><topic>Multiple Organ Failure - etiology</topic><topic>Multiple Organ Failure - mortality</topic><topic>Multivariate analysis</topic><topic>Necrosis</topic><topic>Organ failure</topic><topic>Pancreas</topic><topic>Pancreas - pathology</topic><topic>Pancreatitis</topic><topic>Pancreatitis - blood</topic><topic>Pancreatitis - complications</topic><topic>Pancreatitis - mortality</topic><topic>Pancreatitis, Acute Necrotizing - blood</topic><topic>Patients</topic><topic>Prognosis</topic><topic>Retrospective Studies</topic><topic>Risk Factors</topic><topic>Severity</topic><topic>Treatment Outcome</topic><topic>Triglycerides</topic><topic>Triglycerides - blood</topic><topic>Variables</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pascual, Isabel</creatorcontrib><creatorcontrib>Sanahuja, Ana</creatorcontrib><creatorcontrib>García, Natalia</creatorcontrib><creatorcontrib>Vázquez, Paola</creatorcontrib><creatorcontrib>Moreno, Oswaldo</creatorcontrib><creatorcontrib>Tosca, Joan</creatorcontrib><creatorcontrib>Peña, Andrés</creatorcontrib><creatorcontrib>Garayoa, Ana</creatorcontrib><creatorcontrib>Lluch, Paloma</creatorcontrib><creatorcontrib>Mora, Francisco</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.]</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pascual, Isabel</au><au>Sanahuja, Ana</au><au>García, Natalia</au><au>Vázquez, Paola</au><au>Moreno, Oswaldo</au><au>Tosca, Joan</au><au>Peña, Andrés</au><au>Garayoa, Ana</au><au>Lluch, Paloma</au><au>Mora, Francisco</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association of elevated serum triglyceride levels with a more severe course of acute pancreatitis: Cohort analysis of 1457 patients</atitle><jtitle>Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.]</jtitle><addtitle>Pancreatology</addtitle><date>2019-07</date><risdate>2019</risdate><volume>19</volume><issue>5</issue><spage>623</spage><epage>629</epage><pages>623-629</pages><issn>1424-3903</issn><eissn>1424-3911</eissn><abstract>Previous publications have reported an association between hypertriglyceridemia (HTG) and severity of acute pancreatitis, but this relationship remains somewhat controversial.
To evaluate the outcome of acute pancreatitis according to serum triglyceride levels on admission.
Retrospective analysis of prospectively collected data, which included all consecutive cases of acute pancreatitis admitted to a tertiary hospital (January 2002–December 2014). Acute pancreatitis patients were classified into 3 groups based on serum triglyceride levels (mg/dl) measured within 48 h from admission: normal triglycerides-mild HTG (<200); moderate HTG (200–749); severe HTG (≥750). Primary outcomes were the difference in organ failure, pancreatic necrosis, acute peripancreatic collections and mortality among the three groups.
A total of 1,457 cases were included: 1,335 with normal-mild HTG, 77 with moderate HTG and 45 with severe HTG. The rates of organ failure (11.2% in normal-mild HTG group, 15.6% in moderate HTG and 20.0% in severe HTG), persistent multiple organ failure (2.5% vs. 5.2% vs. 6.7%), pancreatic necrosis (9.2% vs. 14.3% vs. 26.7%) and acute collections (21.6% vs. 40.3% vs. 55.6%) increased significantly with hypertriglyceridemia severity grades. On multivariate analysis, triglycerides as a quantitative variable, evaluated in increments of 100 mg/dl, was independently associated with organ failure, pancreatic necrosis, acute collections and mortality (p < 0.05).
Elevated serum triglyceride levels are independently associated with a more severe course of pancreatitis. It must be highlighted the elevated frequency of local complications in patients with HTG that increases proportionally and significantly with HTG severity grades.</abstract><cop>Switzerland</cop><pub>Elsevier B.V</pub><pmid>31229460</pmid><doi>10.1016/j.pan.2019.06.006</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0002-1628-1914</orcidid><orcidid>https://orcid.org/0000-0001-5008-5821</orcidid></addata></record> |
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| ispartof | Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.], 2019-07, Vol.19 (5), p.623-629 |
| issn | 1424-3903 1424-3911 |
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| source | Elsevier |
| subjects | Acute Disease Acute pancreatitis Adolescent Adult Age Aged Aged, 80 and over Body mass index Cohort analysis Cohort Studies Comorbidity Data collection Diabetes Etiology Failure Female Humans Hypertriglyceridemia Hypertriglyceridemia - blood Hypertriglyceridemia - complications Hypertriglyceridemia - mortality Hypertriglyceridemic pancreatitis Male Metabolism Middle Aged Mortality Multiple Organ Failure - etiology Multiple Organ Failure - mortality Multivariate analysis Necrosis Organ failure Pancreas Pancreas - pathology Pancreatitis Pancreatitis - blood Pancreatitis - complications Pancreatitis - mortality Pancreatitis, Acute Necrotizing - blood Patients Prognosis Retrospective Studies Risk Factors Severity Treatment Outcome Triglycerides Triglycerides - blood Variables Young Adult |
| title | Association of elevated serum triglyceride levels with a more severe course of acute pancreatitis: Cohort analysis of 1457 patients |
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