Bacupari (Garcinia brasiliensis) extract modulates intestinal microbiota and reduces oxidative stress and inflammation in obese rats

The objective of this study was to evaluate the effects of an ethanolic extract of the bark of bacupari (Garcinia brasiliensis – EEB) on the abundance of intestinal microbiota, concentration of short-chain fatty acids (SCFAs), oxidative stress, and inflammation in obese rats fed a high-fat diet (HFD...

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Bibliographic Details
Published in:Food research international 2019-08, Vol.122, p.199-208
Main Authors: Araújo, Fernanda de Oliveira, Moreira, Maria Eliza de Castro, Lima, Cássio Furtado, Toledo, Renata Celi Lopes, de Sousa, Andressa Rodrigues, Veloso, Marcia Paranho, de Freitas, Poliany Graziella, dos Santos, Marcelo Henrique, de Souza, Eliana Carla Gomes, Mantovani, Hilário Cuquetto, Martino, Hercia Stampini Duarte
Format: Article
Language:English
Subjects:
Antioxidant
Inflammation
Intestinal microbiota
Oxidative stress
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Summary:The objective of this study was to evaluate the effects of an ethanolic extract of the bark of bacupari (Garcinia brasiliensis – EEB) on the abundance of intestinal microbiota, concentration of short-chain fatty acids (SCFAs), oxidative stress, and inflammation in obese rats fed a high-fat diet (HFD). Male Wistar rats were divided into three groups: an HFD-fed obese control group, a group fed HFD plus EEB (BHFD) at a dose of 300 mg per animal per day (42 mg 7-epiclusianone and 10.76 mg morelloflavone), and a lean control group fed an AIN-93 M diet for 8 weeks. EEB decreased (p 
ISSN:0963-9969
1873-7145
DOI:10.1016/j.foodres.2019.04.012