Management of high-risk medulloblastoma

Medulloblastoma is the most common malignant brain tumors in children. Current management combines surgery, radiotherapy, and chemotherapy. Current treatment of medulloblastoma is based on a clinical risk-stratification system that takes into account age, extent of resection and metastatic status. H...

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Bibliographic Details
Published in:Neuro-chirurgie 2021-02, Vol.67 (1), p.61-68
Main Author: Bouffet, E.
Format: Article
Language:English
Subjects:
Craniospinal irradiation
High-risk
Medulloblastoma
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Summary:Medulloblastoma is the most common malignant brain tumors in children. Current management combines surgery, radiotherapy, and chemotherapy. Current treatment of medulloblastoma is based on a clinical risk-stratification system that takes into account age, extent of resection and metastatic status. High-risk medulloblastoma patients are defined by the presence of metastatic disease and/or an incomplete resection with a residual amount of tumour>1.5 cm2. This review describes the evolution in the management of high-risk medulloblastoma patients during recent 4 decades and recent changes in the definition of high-risk patients as a result of major advances in the understanding of the molecular heterogeneity of medulloblastomas.
ISSN:0028-3770
1773-0619
DOI:10.1016/j.neuchi.2019.05.007