Incorporating Patient Preferences in Noninferiority Trials

This Viewpoint discusses the selection and interpretation of noninferiority margins (ΔNIs) in noninferiority trials, reviews techniques for eliciting patient preferences for treatment, and calls for using those preferences to select ΔNIs to better achieve patient-centered trade-offs between efficacy...

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Bibliographic Details
Published in:JAMA : the journal of the American Medical Association 2019-07, Vol.322 (4), p.305-306
Main Authors: Acuna, Sergio A, Chesney, Tyler R, Baxter, Nancy N
Format: Article
Language:English
Subjects:
Clinical outcomes
Clinical trials
Medical treatment
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Summary:This Viewpoint discusses the selection and interpretation of noninferiority margins (ΔNIs) in noninferiority trials, reviews techniques for eliciting patient preferences for treatment, and calls for using those preferences to select ΔNIs to better achieve patient-centered trade-offs between efficacy loss for nonefficacy gains represented by the margin.
ISSN:0098-7484
1538-3598
DOI:10.1001/jama.2019.7059