Sleep deprivation worsened oral ulcers and delayed healing process in an experimental rat model

• Published in: Life sciences (1973) 2019-09, Vol.232, p.116594-116594, Article 116594
• Main Authors: Chen, Pan, Yao, Hongliang, Su, Weiwei, He, Yudong, Cheng, Keling, Wang, Yonggang, Peng, Wei, Li, Peibo
• Format: Article
• Language: English
• Subjects: 8-Hydroxydeoxyguanosine; Adrenocorticotropic hormone; Corticosterone; Cosmetics industry; Cytokines; Data recovery; Deoxyguanosine; Endocrine system; Healing; Health problems; IL-1β; Immunoglobulins; Interleukin 6; Interleukin 8; Malondialdehyde; Monocyte chemoattractant protein; Monocyte chemoattractant protein 1; Monocytes; Mucosa; Neuro-immuno-endocrine system; Oral ulcer; Oxidative stress; Phenols; Quality of life; Sleep deprivation; Superoxide dismutase; Tumor necrosis factor-TNF; Tumor necrosis factor-α; Ulcers; γ-Aminobutyric acid
• ISSN: 0024-3205; 1879-0631
• DOI: 10.1016/j.lfs.2019.116594

Sleep deficiency has been reported to be associated with some oral health problems. Oral ulcers are very common lesions of the oral mucosa, which severely impact patients' quality of life. However, the association between sleep deficiency and the oral ulcer remains unknown. The present study aims to explore the effects of sleep deficiency on oral ulcers. Rats were divided into normal control group (n = 30) and oral ulcer group (OU group, n = 50). Model rats with phenol-induced oral ulcers were deprived of sleep for 72 h by using the modified multiple platform technique. Sleep deprivation worsened oral ulcers and delayed healing process in rats. In addition, sleep deprivation increased the γ-aminobutyric acid (GABA, P