Vitamin D Status in Paget Disease of Bone and Efficacy–Safety Profile of Cholecalciferol Treatment in Pagetic Patients with Hypovitaminosis D

Adequate vitamin D status is essential for skeletal health. Paget’s disease of bone (PDB) is a common metabolic skeletal disorder, but data regarding the vitamin D status in PDB patients are lacking. We performed a case–control study to estimate vitamin D status in 708 PDB patients and in 1803 healt...

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Published in:Calcified tissue international 2019-10, Vol.105 (4), p.412-422
Main Authors: Rendina, Domenico, De Filippo, Gianpaolo, Merlotti, Daniela, Di Stefano, Marco, Succoio, Mariangela, Muggianu, Simona Maria, Bianciardi, Simone, D’Elia, Lanfranco, Coppo, Eleonora, Faraonio, Raffaella, Nuti, Ranuccio, Strazzullo, Pasquale, Gennari, Luigi
Format: Article
Language:English
Subjects:
Biochemistry
Biomedical and Life Sciences
Cell Biology
Endocrinology
Life Sciences
Metabolism
Nephrolithiasis
Original Research
Orthopedics
Pain
Parathyroid hormone
Quality of life
Risk factors
Vitamin D
Vitamin deficiency
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Summary:Adequate vitamin D status is essential for skeletal health. Paget’s disease of bone (PDB) is a common metabolic skeletal disorder, but data regarding the vitamin D status in PDB patients are lacking. We performed a case–control study to estimate vitamin D status in 708 PDB patients and in 1803 healthy controls from Italy and an observational prospective study to evaluate the efficacy–safety profile of oral cholecalciferol treatment [400.000 International Units (UI) of cholecalciferol administered in cycles of 8 weeks until 25OHD levels reaches 70 nmol/L as primary therapy and 50.000 UI of cholecalciferol administered every 2 weeks for 52 weeks for the maintenance therapy] in 82 PDB patients with hypovitaminosis D, i.e., 25OHD 
ISSN:0171-967X
1432-0827
DOI:10.1007/s00223-019-00578-1