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Proinsulin/insulin ratio as a predictor of insulin resistance in patients with diabetic nephropathy

Patients with Diabetic nephropathy (DN) have an increase in cardiovascular mortality, and since IR may be a contributing factor. Therefore, the aim of this study was to assess the role of pro insulin/insulin ratio as a predictor of insulin resistance in patients with diabetic nephropathy A Case-cont...

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Bibliographic Details
Published in:Diabetes & metabolic syndrome clinical research & reviews 2019-05, Vol.13 (3), p.2057-2060
Main Authors: El-Messallamy, Fawzy A.F., El-Ashmawy, Hazem M., El shabrawy, Arafa M., Radwan, Samia E.
Format: Article
Language:English
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Summary:Patients with Diabetic nephropathy (DN) have an increase in cardiovascular mortality, and since IR may be a contributing factor. Therefore, the aim of this study was to assess the role of pro insulin/insulin ratio as a predictor of insulin resistance in patients with diabetic nephropathy A Case-control study was conducted in a total of 50 patients who diagnosed with type 2 diabetes mellitus from July 2017 to March 2018. The patients were divided into 2 groups according to presence of diabetic nephropathy. Demographic and clinical data were collected. There is a significant increase in serum pro insulin/insulin ratio in patients with diabetic nephropathy patients compared to patients without diabetic nephropathy An association was found between increase serum pro insulin/insulin ratio and increase predicting of insulin resistance. Cut-off value of serum pro insulin/insulin ratio ≥0.1145 with sensitivity and specificity of 92.3 and 60.3 respectively as a predictor for insulin resistance This study demonstrate a strong relationship between insulin resistance and CKD and this relationship was stronger in the presence of obesity. Pro insulin/insulin ratio was found to be a significant predictor for insulin resistance.
ISSN:1871-4021
1878-0334
DOI:10.1016/j.dsx.2019.04.036