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Proinsulin/insulin ratio as a predictor of insulin resistance in patients with diabetic nephropathy
Patients with Diabetic nephropathy (DN) have an increase in cardiovascular mortality, and since IR may be a contributing factor. Therefore, the aim of this study was to assess the role of pro insulin/insulin ratio as a predictor of insulin resistance in patients with diabetic nephropathy A Case-cont...
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| Published in: | Diabetes & metabolic syndrome clinical research & reviews 2019-05, Vol.13 (3), p.2057-2060 |
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| Main Authors: | , , , |
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| container_end_page | 2060 |
| container_issue | 3 |
| container_start_page | 2057 |
| container_title | Diabetes & metabolic syndrome clinical research & reviews |
| container_volume | 13 |
| creator | El-Messallamy, Fawzy A.F. El-Ashmawy, Hazem M. El shabrawy, Arafa M. Radwan, Samia E. |
| description | Patients with Diabetic nephropathy (DN) have an increase in cardiovascular mortality, and since IR may be a contributing factor. Therefore, the aim of this study was to assess the role of pro insulin/insulin ratio as a predictor of insulin resistance in patients with diabetic nephropathy
A Case-control study was conducted in a total of 50 patients who diagnosed with type 2 diabetes mellitus from July 2017 to March 2018. The patients were divided into 2 groups according to presence of diabetic nephropathy. Demographic and clinical data were collected.
There is a significant increase in serum pro insulin/insulin ratio in patients with diabetic nephropathy patients compared to patients without diabetic nephropathy An association was found between increase serum pro insulin/insulin ratio and increase predicting of insulin resistance. Cut-off value of serum pro insulin/insulin ratio ≥0.1145 with sensitivity and specificity of 92.3 and 60.3 respectively as a predictor for insulin resistance
This study demonstrate a strong relationship between insulin resistance and CKD and this relationship was stronger in the presence of obesity. Pro insulin/insulin ratio was found to be a significant predictor for insulin resistance. |
| doi_str_mv | 10.1016/j.dsx.2019.04.036 |
| format | article |
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A Case-control study was conducted in a total of 50 patients who diagnosed with type 2 diabetes mellitus from July 2017 to March 2018. The patients were divided into 2 groups according to presence of diabetic nephropathy. Demographic and clinical data were collected.
There is a significant increase in serum pro insulin/insulin ratio in patients with diabetic nephropathy patients compared to patients without diabetic nephropathy An association was found between increase serum pro insulin/insulin ratio and increase predicting of insulin resistance. Cut-off value of serum pro insulin/insulin ratio ≥0.1145 with sensitivity and specificity of 92.3 and 60.3 respectively as a predictor for insulin resistance
This study demonstrate a strong relationship between insulin resistance and CKD and this relationship was stronger in the presence of obesity. Pro insulin/insulin ratio was found to be a significant predictor for insulin resistance.</description><identifier>ISSN: 1871-4021</identifier><identifier>EISSN: 1878-0334</identifier><identifier>DOI: 10.1016/j.dsx.2019.04.036</identifier><identifier>PMID: 31235136</identifier><language>eng</language><publisher>Netherlands: Elsevier Ltd</publisher><subject>Biomarkers - blood ; Blood Glucose - analysis ; Case-Control Studies ; Diabetes Mellitus, Type 2 - physiopathology ; Diabetic Nephropathies - complications ; Diabetic nephropathy ; Female ; Follow-Up Studies ; Glucose Intolerance - blood ; Glucose Intolerance - diagnosis ; Glucose Intolerance - etiology ; Glycated Hemoglobin A - analysis ; Humans ; Insulin - blood ; Insulin Resistance ; Male ; Middle Aged ; Pro insulin /insulin ratio ; Prognosis ; Proinsulin - blood ; Type 2 diabetes mellitus</subject><ispartof>Diabetes & metabolic syndrome clinical research & reviews, 2019-05, Vol.13 (3), p.2057-2060</ispartof><rights>2019 Diabetes India</rights><rights>Copyright © 2019 Diabetes India. Published by Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c353t-c622ec2b3c331bf9dd5afaea0273bc60b637f71945b1a0c034b344a97f977b913</citedby><cites>FETCH-LOGICAL-c353t-c622ec2b3c331bf9dd5afaea0273bc60b637f71945b1a0c034b344a97f977b913</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31235136$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>El-Messallamy, Fawzy A.F.</creatorcontrib><creatorcontrib>El-Ashmawy, Hazem M.</creatorcontrib><creatorcontrib>El shabrawy, Arafa M.</creatorcontrib><creatorcontrib>Radwan, Samia E.</creatorcontrib><title>Proinsulin/insulin ratio as a predictor of insulin resistance in patients with diabetic nephropathy</title><title>Diabetes & metabolic syndrome clinical research & reviews</title><addtitle>Diabetes Metab Syndr</addtitle><description>Patients with Diabetic nephropathy (DN) have an increase in cardiovascular mortality, and since IR may be a contributing factor. Therefore, the aim of this study was to assess the role of pro insulin/insulin ratio as a predictor of insulin resistance in patients with diabetic nephropathy
A Case-control study was conducted in a total of 50 patients who diagnosed with type 2 diabetes mellitus from July 2017 to March 2018. The patients were divided into 2 groups according to presence of diabetic nephropathy. Demographic and clinical data were collected.
There is a significant increase in serum pro insulin/insulin ratio in patients with diabetic nephropathy patients compared to patients without diabetic nephropathy An association was found between increase serum pro insulin/insulin ratio and increase predicting of insulin resistance. Cut-off value of serum pro insulin/insulin ratio ≥0.1145 with sensitivity and specificity of 92.3 and 60.3 respectively as a predictor for insulin resistance
This study demonstrate a strong relationship between insulin resistance and CKD and this relationship was stronger in the presence of obesity. Pro insulin/insulin ratio was found to be a significant predictor for insulin resistance.</description><subject>Biomarkers - blood</subject><subject>Blood Glucose - analysis</subject><subject>Case-Control Studies</subject><subject>Diabetes Mellitus, Type 2 - physiopathology</subject><subject>Diabetic Nephropathies - complications</subject><subject>Diabetic nephropathy</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Glucose Intolerance - blood</subject><subject>Glucose Intolerance - diagnosis</subject><subject>Glucose Intolerance - etiology</subject><subject>Glycated Hemoglobin A - analysis</subject><subject>Humans</subject><subject>Insulin - blood</subject><subject>Insulin Resistance</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Pro insulin /insulin ratio</subject><subject>Prognosis</subject><subject>Proinsulin - blood</subject><subject>Type 2 diabetes mellitus</subject><issn>1871-4021</issn><issn>1878-0334</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNp9kMlOwzAQhi0EoqXwAFyQj1wSvCWpxQkhNqkSHOBs2c5EddXGwXZZ3h6Xlh45zWj-RZoPoXNKSkpofbUo2_hVMkJlSURJeH2AxnTaTAvCuTj83WkhCKMjdBLjgpCqkkweoxGnjFeU12NkX4J3fVwvXX-1mzjo5DzWEWs8BGidTT5g3-G9DtHFpHsL-YSH7IY-Rfzp0hy3ThtIzuIehnnwWZx_n6KjTi8jnO3mBL3d373ePhaz54en25tZYXnFU2FrxsAywy3n1HSybSvdadCENdzYmpiaN11DpagM1cQSLgwXQsumk01jJOUTdLntHYJ_X0NMauWiheVS9-DXUTEmaklqmvsmiG6tNvgYA3RqCG6lw7eiRG3YqoXKbNWGrSJCZbY5c7GrX5sVtPvEH8xsuN4aID_54SCoaDMamxEGsEm13v1T_wP2b4u6</recordid><startdate>201905</startdate><enddate>201905</enddate><creator>El-Messallamy, Fawzy A.F.</creator><creator>El-Ashmawy, Hazem M.</creator><creator>El shabrawy, Arafa M.</creator><creator>Radwan, Samia E.</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201905</creationdate><title>Proinsulin/insulin ratio as a predictor of insulin resistance in patients with diabetic nephropathy</title><author>El-Messallamy, Fawzy A.F. ; El-Ashmawy, Hazem M. ; El shabrawy, Arafa M. ; Radwan, Samia E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c353t-c622ec2b3c331bf9dd5afaea0273bc60b637f71945b1a0c034b344a97f977b913</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Biomarkers - blood</topic><topic>Blood Glucose - analysis</topic><topic>Case-Control Studies</topic><topic>Diabetes Mellitus, Type 2 - physiopathology</topic><topic>Diabetic Nephropathies - complications</topic><topic>Diabetic nephropathy</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Glucose Intolerance - blood</topic><topic>Glucose Intolerance - diagnosis</topic><topic>Glucose Intolerance - etiology</topic><topic>Glycated Hemoglobin A - analysis</topic><topic>Humans</topic><topic>Insulin - blood</topic><topic>Insulin Resistance</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Pro insulin /insulin ratio</topic><topic>Prognosis</topic><topic>Proinsulin - blood</topic><topic>Type 2 diabetes mellitus</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>El-Messallamy, Fawzy A.F.</creatorcontrib><creatorcontrib>El-Ashmawy, Hazem M.</creatorcontrib><creatorcontrib>El shabrawy, Arafa M.</creatorcontrib><creatorcontrib>Radwan, Samia E.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Diabetes & metabolic syndrome clinical research & reviews</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>El-Messallamy, Fawzy A.F.</au><au>El-Ashmawy, Hazem M.</au><au>El shabrawy, Arafa M.</au><au>Radwan, Samia E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Proinsulin/insulin ratio as a predictor of insulin resistance in patients with diabetic nephropathy</atitle><jtitle>Diabetes & metabolic syndrome clinical research & reviews</jtitle><addtitle>Diabetes Metab Syndr</addtitle><date>2019-05</date><risdate>2019</risdate><volume>13</volume><issue>3</issue><spage>2057</spage><epage>2060</epage><pages>2057-2060</pages><issn>1871-4021</issn><eissn>1878-0334</eissn><abstract>Patients with Diabetic nephropathy (DN) have an increase in cardiovascular mortality, and since IR may be a contributing factor. Therefore, the aim of this study was to assess the role of pro insulin/insulin ratio as a predictor of insulin resistance in patients with diabetic nephropathy
A Case-control study was conducted in a total of 50 patients who diagnosed with type 2 diabetes mellitus from July 2017 to March 2018. The patients were divided into 2 groups according to presence of diabetic nephropathy. Demographic and clinical data were collected.
There is a significant increase in serum pro insulin/insulin ratio in patients with diabetic nephropathy patients compared to patients without diabetic nephropathy An association was found between increase serum pro insulin/insulin ratio and increase predicting of insulin resistance. Cut-off value of serum pro insulin/insulin ratio ≥0.1145 with sensitivity and specificity of 92.3 and 60.3 respectively as a predictor for insulin resistance
This study demonstrate a strong relationship between insulin resistance and CKD and this relationship was stronger in the presence of obesity. Pro insulin/insulin ratio was found to be a significant predictor for insulin resistance.</abstract><cop>Netherlands</cop><pub>Elsevier Ltd</pub><pmid>31235136</pmid><doi>10.1016/j.dsx.2019.04.036</doi><tpages>4</tpages></addata></record> |
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| ispartof | Diabetes & metabolic syndrome clinical research & reviews, 2019-05, Vol.13 (3), p.2057-2060 |
| issn | 1871-4021 1878-0334 |
| language | eng |
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| source | Elsevier |
| subjects | Biomarkers - blood Blood Glucose - analysis Case-Control Studies Diabetes Mellitus, Type 2 - physiopathology Diabetic Nephropathies - complications Diabetic nephropathy Female Follow-Up Studies Glucose Intolerance - blood Glucose Intolerance - diagnosis Glucose Intolerance - etiology Glycated Hemoglobin A - analysis Humans Insulin - blood Insulin Resistance Male Middle Aged Pro insulin /insulin ratio Prognosis Proinsulin - blood Type 2 diabetes mellitus |
| title | Proinsulin/insulin ratio as a predictor of insulin resistance in patients with diabetic nephropathy |
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