Study of relationship between total vitamin D level and NAFLD in a sample of Egyptian patients with and without T2DM

Non-alcoholic fatty liver disease (NAFLD) is increasing recently due to increasing the prevalence of obesity. Insulin resistance (IR) is the mutual pathological cause for both T2DM and NAFLD. Vitamin D acts against IR by its anti-inflammatory and regulation of insulin secretion as pancreatic beta ce...

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Published in:Diabetes & metabolic syndrome clinical research & reviews 2019-05, Vol.13 (3), p.1769-1771
Main Authors: Hosny, Salwa Seddik, Ali, Hanan Mahmoud, Mohammed, Wesam Ahmed, El Ghannam, Mohamed Hesham
Format: Article
Language:English
Subjects:
Diabetes Mellitus, Type 2 - complications
Humans
Insulin Resistance
Non-alcoholic Fatty Liver Disease - blood
Non-alcoholic Fatty Liver Disease - etiology
Non-alcoholic Fatty Liver Disease - pathology
T2DM and NAFLD
Total vitamin D
Vitamin D - blood
Vitamin D Deficiency - physiopathology
Vitamins - blood
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Summary:Non-alcoholic fatty liver disease (NAFLD) is increasing recently due to increasing the prevalence of obesity. Insulin resistance (IR) is the mutual pathological cause for both T2DM and NAFLD. Vitamin D acts against IR by its anti-inflammatory and regulation of insulin secretion as pancreatic beta cells express vitamin D receptor (VDR). Assessment of relationship between Total vitamin D level and NAFLD a sample of Egyptian patients with and without T2DM. The current study included 110 Egyptian subjects. They divided into 4 groups: Group 1: 30 diabetic patients with NAFLD Group 2: 30 diabetic patients without NAFLD Group 3: 30 NAFLD patients without diabetes Group 4: 20 healthy controls. Vitamin D level assessment, AST, ALT, GGT, total cholesterol, LDL, triglycerides, fasting and 2 h post prandial plasma glucose, glycosylated hemoglobin, albumin and creatinine calculation of FLI were assessed. There was a statistical significant decrease in total vitamin D level in T2DM patients with NAFLD than either T2DM or NAFLD only patients.(15.5 ± 7.46 vs 24.4 ± 8.19 and 22.86 ± 9.58 ng/ml respectively) also Total vitamin D level is negatively correlated with age, weight, BMI, WC, total cholesterol, LDL, TG, FPG, HbA1c and FLI. There is a decrease in total vitamin D in T2DM patients with NAFLD.
ISSN:1871-4021
1878-0334
DOI:10.1016/j.dsx.2019.04.002