Age-Dependent Effects of NO on Rhythmic Activity of Postganglionic Sympathetic Fibers

We studied the effects of exogenous NO donor (sodium nitroprusside) and NO synthesis blocker (100 μM L-NAME) on baseline electrical activity of postganglionic fibers in the sympathetic superior cervical in rats during postnatal ontogeny. Starting the age of 20 days, sodium nitroprusside increased th...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2019-06, Vol.167 (2), p.191-193
Main Authors: Moiseev, K. Yu, Verbovetskaya, A. I., Maslyukov, A. P., Maslyukov, P. M.
Format: Article
Language:English
Subjects:
Aging
Animals
Autonomic nervous system
Biomedical and Life Sciences
Biomedicine
Cell Biology
Female
Fibers
Ganglia, Sympathetic - drug effects
Internal Medicine
Laboratory Medicine
NG-Nitroarginine methyl ester
NG-Nitroarginine Methyl Ester - pharmacology
Nitric oxide
Nitroprusside - pharmacology
Ontogeny
Pathology
Physiology
Rats
Rats, Wistar
Rhythms
Sodium
Sodium nitroferricyanide
Sodium nitroprusside
Sympathetic Fibers, Postganglionic - drug effects
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Summary:We studied the effects of exogenous NO donor (sodium nitroprusside) and NO synthesis blocker (100 μM L-NAME) on baseline electrical activity of postganglionic fibers in the sympathetic superior cervical in rats during postnatal ontogeny. Starting the age of 20 days, sodium nitroprusside increased the mean discharge amplitude and the spectrum power in the respiratory (0.7-1.5 Hz) and cardiac (4-7 Hz) frequency bands. In contrast, application of L-NAME for 1 h decreased the spectrum power in these bands. Both agents produced no significant effect on the rhythmic sympathetic discharges at frequencies >8 Hz.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-019-04488-y