State of Colon Microbiota in Rats during Chronic Restraint Stress and Selank Treatment

We studied the effects of Selank on intestinal microbiota in Wistar male rats subjected to chronic restraint stress. Selank was injected intraperitoneally in doses of 80, 250 and 750 μg/kg 15 min before stress exposure. Chronic restraint stress led to a decrease in the content of obligate microflora...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2019-06, Vol.167 (2), p.226-228
Main Authors: Mukhina, A. Yu, Medvedeva, O. A., Svishcheva, M. V., Shevchenko, A. V., Efremova, N. N., Bobyntsev, I. I., Kalutskii, P. V., Andreeva, L. A., Myasoedov, N. F.
Format: Article
Language:English
Subjects:
Animals
Biomedical and Life Sciences
Biomedicine
Cell Biology
Colon
Colon - microbiology
Disease Models, Animal
Gastrointestinal Microbiome - drug effects
Internal Medicine
Intestinal microflora
Intestine
Laboratory Medicine
Male
Microbiota
Microbiota (Symbiotic organisms)
Oligopeptides - therapeutic use
Pathology
Rats
Rats, Wistar
Restraint, Physical - physiology
Rodents
Stress (Psychology)
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Summary:We studied the effects of Selank on intestinal microbiota in Wistar male rats subjected to chronic restraint stress. Selank was injected intraperitoneally in doses of 80, 250 and 750 μg/kg 15 min before stress exposure. Chronic restraint stress led to a decrease in the content of obligate microflora, while the content of opportunistic microorganisms increased. Selank restored intestinal microbiota presumably via central (neurotropic) and peripheral (immunotropic) mechanisms.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-019-04496-y