Loading…

Low-Molecular Weight Metabolites from Polyphenols as Effectors for Attenuating Neuroinflammation

Age-associated pathophysiological changes such as neurodegenerative diseases are multifactorial conditions with increasing incidence and no existing cure. The possibility of altering the progression and development of these multifactorial diseases through diet is an attractive approach with increasi...

Full description

Saved in:
Bibliographic Details
Published in:Journal of agricultural and food chemistry 2020-02, Vol.68 (7), p.1790-1807
Main Authors: Carregosa, Diogo, Carecho, Rafael, Figueira, Inês, N Santos, Cláudia
Format: Article
Language:English
Subjects:
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Age-associated pathophysiological changes such as neurodegenerative diseases are multifactorial conditions with increasing incidence and no existing cure. The possibility of altering the progression and development of these multifactorial diseases through diet is an attractive approach with increasing supporting data. Epidemiological and clinical studies have highlighted the health potential of diets rich in fruits and vegetables. Such food sources are rich in (poly)­phenols, natural compounds increasingly associated with health benefits, having the potential to prevent or retard the development of various diseases. However, absorption and the blood concentration of (poly)­phenols is very low when compared with their corresponding (poly)­phenolic metabolites. Therefore, these serum-bioavailable metabolites are much more promising candidates to overcome cellular barriers and reach target tissues, such as the brain. Bearing this in mind, it will be reviewed that the molecular mechanisms underlying (poly)­phenolic metabolites effects, range from 0.1 to
ISSN:0021-8561
1520-5118
DOI:10.1021/acs.jafc.9b02155