Effect of Estriol, Chorionic Gonadotropin, and Oncostatin M on the Expression of Recombinase RAG-1 in Regulatory T Lymphocyte Subpopulations

We studied the effect of estriol, chorionic gonadotropin, oncostatin M, and hormone-cytokine combinations on the expression of recombinase RAG-1 in T-regulatory (Treg) and T helper 17 (Th17) lymphocytes. It was found that estriol in a concentration corresponding to the first trimester of pregnancy i...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2019-05, Vol.167 (1), p.57-61
Main Authors: Shirshev, S. V., Nekrasova, I. V., Gorbunova, O. L., Orlova, E. G.
Format: Article
Language:English
Subjects:
Biomedical and Life Sciences
Biomedicine
CD4 antigen
CD4-Positive T-Lymphocytes - drug effects
CD4-Positive T-Lymphocytes - metabolism
Cell Biology
Cells, Cultured
Chorionic gonadotropin
Chorionic Gonadotropin - pharmacology
Chorionic gonadotropins
Cytokines
Estriol - pharmacology
Female
Forkhead Transcription Factors - metabolism
Foxp3 protein
Gonadotropins
Helper cells
Hormones
Humans
Immunological tolerance
Internal Medicine
Laboratory Medicine
Lymphocytes
Lymphocytes T
Oncostatin M
Oncostatin M - pharmacology
Pathology
Pituitary (anterior)
Placental hormones
Pregnancy
RAG1 protein
Recombinase
Recombinases - metabolism
T cell receptors
T cells
T-Lymphocytes, Regulatory - drug effects
T-Lymphocytes, Regulatory - enzymology
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Summary:We studied the effect of estriol, chorionic gonadotropin, oncostatin M, and hormone-cytokine combinations on the expression of recombinase RAG-1 in T-regulatory (Treg) and T helper 17 (Th17) lymphocytes. It was found that estriol in a concentration corresponding to the first trimester of pregnancy increased the level of Treg (CD4 + FoxP3 + ) cells and suppressed the formation of Th17 (CD4 + RORC + ) lymphocytes. This effect was nor observed after individual administration of chorionic gonadotropin and oncostatin M, but some combinations of the studied hormones with oncostatin M increased the percentage of CD4 + FOXP3 + cells. In the presence of oncostatin M, the studied hormones enhanced the expression of RAG-1 in CD4 + FoxP3 + cells, but not in CD4 + RORC + cells, thereby initiating of Treg T-cell receptor (TCR) revision. The mechanisms of hormone cytokine control of induction of the immune tolerance during pregnancy are discussed.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-019-04460-w