Analysis of the Action of Quaternized Chitosans with Different Molecular Weight on Anticoagulant Activity of Heparins In Vitro

Quaternized derivatives of chitosan with a substitution degree of 85-98% (highly substituted) synthesized from chitosans with a molecular weight of 5, 10, 20 kDa, with a degree of deacetylation of 89-98%, and the code numbers of QChit 5, QChit 10, QChit 20, respectively, completely neutralize antith...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2019-06, Vol.167 (2), p.279-283
Main Authors: Drozd, N. N., Logvinova, Yu. S., Shagdarova, B. Ts, Il’ina, A. V., Varlamov, V. P.
Format: Article
Language:English
Subjects:
Anticoagulants
Anticoagulants (Medicine)
Anticoagulants - chemistry
Anticoagulants - pharmacology
Antithrombin
Biomedical and Life Sciences
Biomedicine
Blood Coagulation Tests
Cell Biology
Chitosan
Chitosan - chemistry
Deacetylation
Hemolysis - drug effects
Heparin
Heparin - chemistry
Heparin - pharmacology
Humans
Internal Medicine
Laboratory Medicine
Molecular weight
Pathology
Platelet aggregation
Platelet Aggregation - drug effects
Protamine sulfate
Sulfates
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Summary:Quaternized derivatives of chitosan with a substitution degree of 85-98% (highly substituted) synthesized from chitosans with a molecular weight of 5, 10, 20 kDa, with a degree of deacetylation of 89-98%, and the code numbers of QChit 5, QChit 10, QChit 20, respectively, completely neutralize antithrombin activity of unfractionated heparin and partially neutralize aXa activity of low-molecular-weight heparin (clexane), similar to protamine sulfate. The advantages of QChit 5 and QChit 10 over QChit 20 and protamine sulphate are the follows: the effect is achieved at lower concentrations and in greater concentration range; they do not promote platelet aggregation; in a concentration of 0.0072 mg/ml they do not destroy the erythrocyte membranes.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-019-04509-w