Effects of Cocarboxylase in Amikacin-Induced Ototoxicity in Immature Animals

Possible otoprotective properties of cocarboxylase were studied on the model of amikacin-induced ototoxicity in immature rabbits. Auditory function was evaluated by the short-latency auditory brainstem response (ABR) and distortion product otoacoustic emission (DPOAE) tests. Administration of cocarb...

Full description

Saved in:
Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2019-06, Vol.167 (2), p.250-254
Main Authors: Ischanova, Yu. S., Rakhmanova, I. V., D’yakonova, I. N.
Format: Article
Language:English
Subjects:
Age Factors
Amikacin
Amikacin - pharmacology
Animals
Auditory system
Biomedical and Life Sciences
Biomedicine
Brain stem
Cell Biology
Evoked Potentials, Auditory, Brain Stem - drug effects
Hair cells
Infants (Premature)
Internal Medicine
Laboratory Medicine
Latency
Neonatology
Otoacoustic Emissions, Spontaneous - drug effects
Ototoxicity
Outer hair cells
Pathology
Pharmacology and Toxicology
Rabbits
Random Allocation
Thiamine Pyrophosphate - metabolism
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Possible otoprotective properties of cocarboxylase were studied on the model of amikacin-induced ototoxicity in immature rabbits. Auditory function was evaluated by the short-latency auditory brainstem response (ABR) and distortion product otoacoustic emission (DPOAE) tests. Administration of cocarboxylase after modeling of amikacin-induced ototoxicity resulted in a decrease in the ABR peak I threshold and prevented damage to the outer hair cells.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-019-04502-3