The CHOPIn Study: a Multicenter Study on Cerebellar Hemorrhage and Outcome in Preterm Infants

• Published in: Cerebellum (London, England) England), 2019-12, Vol.18 (6), p.989-998
• Main Authors: Boswinkel, V., Steggerda, S. J., Fumagalli, M., Parodi, A., Ramenghi, L. A., Groenendaal, F., Dudink, J., Benders, M. N., Knol, R., de Vries, L. S., van Wezel-Meijler, G.
• Format: Article
• Language: English
• Subjects: Adolescent; Adult; Biomedical and Life Sciences; Biomedicine; Cerebellar Diseases - diagnostic imaging; Cerebellar Diseases - mortality; Cerebellar Diseases - physiopathology; Cerebellum; Child, Preschool; Female; Follow-Up Studies; Hemorrhage; Humans; Infant, Newborn; Infant, Premature - physiology; Infants; Magnetic resonance imaging; Magnetic Resonance Imaging - trends; Male; Middle Aged; Neurobiology; Neurodevelopment; Neurology; Neurosciences; Newborn babies; Original Paper; Premature birth; Retrospective Studies; Treatment Outcome; Young Adult
• ISSN: 1473-4222; 1473-4230
• DOI: 10.1007/s12311-019-01053-1

Cerebellar hemorrhage (CBH) is a frequent complication of preterm birth and may play an important and under-recognized role in neurodevelopment outcome. Association between CBH size, location, and neurodevelopment is still unknown. The main objective of this study was to investigate neurodevelopmental outcome at 2 years of age in a large number of infants with different patterns of CBH. Of preterm infants (≤ 34 weeks) with known CBH, perinatal factors, neuro-imaging findings, and follow-up at 2 years of age were retrospectively collected. MRI scans were reassessed to determine the exact size, number, and location of CBH. CBH was divided into three groups: punctate (≤ 4 mm), limited (> 4 mm but