Preferential Tumor Accumulation of Polyglycerol Functionalized Nanodiamond Conjugated with Cyanine Dye Leading to Near‐Infrared Fluorescence In Vivo Tumor Imaging

Preferential accumulation of nanoparticles in a tumor is realized commonly by combined effects of active and passive targeting. However, passive targeting based on an enhanced permeation and retention (EPR) effect is not sufficient to observe clear tumor fluorescence images in most of the in vivo ex...

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Bibliographic Details
Published in:Small (Weinheim an der Bergstrasse, Germany) Germany), 2019-11, Vol.15 (48), p.e1901930-n/a
Main Authors: Yoshino, Fumi, Amano, Tsukuru, Zou, Yajuan, Xu, Jian, Kimura, Fuminori, Furusho, Yoshio, Chano, Tokuhiro, Murakami, Takashi, Zhao, Li, Komatsu, Naoki
Format: Article
Language:English
Subjects:
Accumulation
Blood circulation
Cyanine dyes
Diamonds
EPR effect
Fluorescence
Liver
nanodiamonds
Nanoparticles
Nanostructure
Nanotechnology
Organs
polyglycerol
Polyglycerols
Spleen
stealth effect
tumor imaging
Tumors
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Summary:Preferential accumulation of nanoparticles in a tumor is realized commonly by combined effects of active and passive targeting. However, passive targeting based on an enhanced permeation and retention (EPR) effect is not sufficient to observe clear tumor fluorescence images in most of the in vivo experiments using tumor‐bearing mice. Herein, polyglycerol‐functionalized nanodiamonds (ND‐PG) conjugated with cyanine dye (Cy7) are synthesized and it is found that the resulting ND‐PG‐Cy7 is preferentially accumulated in the tumor, giving clear fluorescence in in vivo and ex vivo fluorescence images. One of the plausible reasons is the longer in vivo blood circulation time of ND‐PG‐Cy7 (half‐life: 58 h determined by the pharmacokinetic analysis) than that of other nanoparticles (half‐life:
ISSN:1613-6810
1613-6829
DOI:10.1002/smll.201901930