The Role of Genetic Variants (rs869109213 and rs2070744) Of the eNOS Gene and BglII in the α2 Subunit of the α2β1 Integrin Gene in Diabetic Retinopathy in a Tunisian Population

Purpose: In this study, we investigated the association of two polymorphisms (rs869109213 and rs2070744) in the eNOS gene and one polymorphism BglII in the α 2 β 1 integrin gene (ITGA2) with the risk of diabetic retinopathy (DR) in a Tunisian population. Methods: The study investigated of 110 type 2...

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Bibliographic Details
Published in:Seminars in ophthalmology 2019-07, Vol.34 (5), p.365-374
Main Authors: Midani, Fatma, Ben Amor, Zohra, El Afrit, Mohamed Ali, Kallel, Amani, Feki, Moncef, Soualmia, Hayet
Format: Article
Language:English
Subjects:
BglII polymorphism
diabetic retinopathy
eNOS polymorphisms
integrin
ITGA2
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Summary:Purpose: In this study, we investigated the association of two polymorphisms (rs869109213 and rs2070744) in the eNOS gene and one polymorphism BglII in the α 2 β 1 integrin gene (ITGA2) with the risk of diabetic retinopathy (DR) in a Tunisian population. Methods: The study investigated of 110 type 2 diabetes mellitus (T2DM) and 127 DR patients. The genotypes of the eNOS 4b/4a (rs869109213) and −786T/C (rs2070744) polymorphisms and of the BglII polymorphism of ITGA2 were studied using the PCR or PCR-RFLP method. Results: The genotype distributions of the two polymorphisms in eNOS 4b4a and eNOS (−786T/C) were significantly different between T2DM and DR patients (p
ISSN:0882-0538
1744-5205
DOI:10.1080/08820538.2019.1632354