Enhanced osteoporotic effect of silicon carbide nanoparticles combine with nano-hydroxyapatite coated anodized titanium implant on healthy bone regeneration in femoral fracture

• Published in: Journal of photochemistry and photobiology. B, Biology Biology, 2019-08, Vol.197, p.111515-111515, Article 111515
• Main Authors: Li, Tao, Li, Xing-Long, Hu, Shi-Xiang, Wu, Jing
• Format: Article
• Language: English
• Subjects: Anodizing; Apatite; Biocompatibility; Biomedical materials; Bone; Bone growth; Calcium; Cell culture; Chemical properties; Deposition; Electrochemistry; Femoral fracture; Femur; Garbage; Histology; Hydroxyapatite; Implantation; Inserts; Integration; Mechanical properties; Nanoparticles; Nanotechnology; Nanotubes; Organic chemistry; Orthopaedic implants; Orthopedics; Osteocalcin; Osteoporosis; Phase composition; Physicochemical properties; Protective coatings; Regeneration; Regeneration (physiology); Silicon; Silicon carbide; Surgical implants; Titanium; Titanium dioxide; Transplants & implants
• ISSN: 1011-1344; 1873-2682
• DOI: 10.1016/j.jphotobiol.2019.111515

An extraordinary arrangement of research is as yet going on in the area of orthopedic implants advancement to determine different issues being looked by the engineering today. In spite of a few detriments of the orthopedic metallic inserts, they keep on being utilized, essentially as a result of their unrivaled mechanical properties. We investigated the conceivable utilization of silicon carbide (SiC) as a nano-ceramic covering material of titanium (Ti)-based all out femoral substitution implants. The thought is to keep wear garbage arrangement from the delicate titanium exterior. Silicon carbide is a hard and firmly holding bio-ceramic surface substance, and in light of these physico-chemical properties, it isn't actually degradable, just like the case with apatite (HA). To improve cytocompatibility and osseous-integration, we deposited anodized titanium nanotubes (TiO2) inserts, by electrochemical deposition method (EDM), with silicon carbide (SiC) with apatite (SiC@HA). The deposition was affirmed by SEM, while phase composition properties were assessed by XRD. Calcium affidavit, osteocalcin creation, and articulation of bone genes were essentially higher in rodent osteoblast cell culture on SiC@HA-covered anodized titanium nanotubes than in cells cultured on uncoated anodized titanium nanotubes. Implantation into rodent femurs likewise demonstrated that the SiC@HA-covered substance had unrivaled osseous-integration movement in correlation with that of customary inserts, as evaluated by in vivo tomography and histology. Therefore, anodized titanium nanotubes covered with SiC@HA holds guarantee as an orthopedic implant substance. [Display omitted] •SiC nanoparticles reinforced hydroxyapatite coatings by electrochemical deposition method.•Pre-osteoblast culture demonstrated the in vitro and in vivo biocompatibility of the coatings.•Live/dead cell assay and cell adhesion demonstrated coatings multifunctionality.•SiC@HA coatings to promote osteogenesis for orthopedic implants.