Influence of maternal protein malnutrition on oxidative stress and regulators of mitochondrial biogenesis in female rat hearts over succeeding generations

We sought to evaluate the effects of maternal protein restriction (LP) on oxidative balance and transcription factors for mitochondrial biogenesis in the hearts of young female rats of both the first (F1) and second (F2) generation. We evaluated oxidative stress biomarkers (lipid peroxidation and pr...

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Bibliographic Details
Published in:Life sciences (1973) 2019-09, Vol.232, p.116579-116579, Article 116579
Main Authors: Silva, Severina Cássia Andrade, Braz, Glauber Rudá Feitoza, do Nascimento, Luciana Caroline Paulino, Santana, David Filipe, da Siva Pedroza, Anderson Apolonio, Silva, Tercya Lucidi Araujo, Fernandes, Mariana Pinheiro, Sellitti, Donald F., Lagranha, Claudia Jacques
Format: Article
Language:English
Subjects:
Animals
Antioxidants
Antioxidants - pharmacology
Biomarkers
Biosynthesis
Catalase
Female
Gene expression
Generations
Glutathione
Glutathione - metabolism
Glutathione transferase
Heart
Heart - drug effects
Heart - physiology
Heredity - genetics
Inheritances
Intergenerational
Lipid peroxidation
Lipid Peroxidation - drug effects
Lipids
Malnutrition
Mitochondria
Mitochondria - drug effects
Mitochondrial biogenesis
Myocardium - metabolism
Nutrition
Organelle Biogenesis
Oxidation
Oxidation-Reduction
Oxidative stress
Oxidative Stress - drug effects
Oxidative Stress - physiology
Peroxidation
Protein-Energy Malnutrition - metabolism
Proteins
Rats
Regulators
Sulfhydryl groups
Superoxide dismutase
Superoxide Dismutase - metabolism
Transcription factors
Transcription Factors - metabolism
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Summary:We sought to evaluate the effects of maternal protein restriction (LP) on oxidative balance and transcription factors for mitochondrial biogenesis in the hearts of young female rats of both the first (F1) and second (F2) generation. We evaluated oxidative stress biomarkers (lipid peroxidation and protein oxidation), enzymatic antioxidant defense (activity of superoxide dismutase-SOD, catalase, and glutathione-S-transferase-GST), nonenzymatic antioxidant defense (reduced glutathione-GSH and sulfhydryl groups) and gene expression of AMPK, PGC-1α and TFAM. Interestingly, lipid peroxidation was decreased (49%, p 
ISSN:0024-3205
1879-0631
DOI:10.1016/j.lfs.2019.116579