Preoperative Thyroid Autoimmune Status and Changes in Thyroid Function and Body Weight After Bariatric Surgery

Background Bariatric surgery has emerged as the most effective therapy for morbid obesity. There is increasing evidence that bariatric surgery could alleviate systemic inflammation and influence thyroid function. The current study aimed to investigate the associations of preoperative thyroid autoimm...

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Bibliographic Details
Published in:Obesity surgery 2019-09, Vol.29 (9), p.2904-2911
Main Authors: Xia, Ming-Feng, Chang, Xin-Xia, Zhu, Xiao-Peng, Yan, Hong-Mei, Shi, Chen-Ye, Wu, Wei, Zhong, Ming, Zeng, Hai-Luan, Bian, Hua, Wu, Hai-Fu, Gao, Xin
Format: Article
Language:English
Subjects:
Adult
Autoantibodies
Autoantigens
Autoimmunity
Bariatric Surgery
Female
Fish oils
Gastrointestinal surgery
Humans
Iodide Peroxidase
Iron-Binding Proteins
Male
Medicine
Medicine & Public Health
Middle Aged
Obesity
Obesity, Morbid - blood
Obesity, Morbid - surgery
Original Contributions
Retrospective Studies
Surgery
Thyroid Function Tests
Thyroid gland
Thyroid Gland - physiopathology
Thyrotropin - blood
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Summary:Background Bariatric surgery has emerged as the most effective therapy for morbid obesity. There is increasing evidence that bariatric surgery could alleviate systemic inflammation and influence thyroid function. The current study aimed to investigate the associations of preoperative thyroid autoimmune status with the changes in body weight and thyroid function after bariatric surgery. Methods We recruited 101 patients with morbid obesity (44 men and 57 women) who received bariatric surgery at Zhongshan Hospital, Fudan University. Those who had used thyroid hormone replacement or antithyroid drugs were excluded. General linear models were used to compare the changes in body weight and thyroid function in participants with different thyroid autoimmune statuses. Results After bariatric surgery, serum-free triiodothyronine (FT3) (4.94 ± 0.73 vs 4.33 ± 0.59 pmol/L, P  
ISSN:0960-8923
1708-0428
DOI:10.1007/s11695-019-03910-8