New trends in glioma cancer therapy: Targeting Na+/H + exchangers

Glioma is the oneof the most prevalent primarybrain tumors. There is a variety of oxidative stresses, inflammatory pathways, apoptosis signaling, and Na+/H + exchangers (NHEs) involved in the pathophysiology of glioma. Previous studies have indicated a relationship between NHEs and some molecular pa...

Full description

Saved in:
Bibliographic Details
Published in:Journal of cellular physiology 2020-02, Vol.235 (2), p.658-665
Main Authors: Tamtaji, Omid Reza, Mirzaei, Hamed, Shamshirian, Amir, Shamshirian, Danial, Behnam, Mohammad, Asemi, Zatollah
Format: Article
Language:English
Subjects:
Animal models
Apoptosis
Brain tumors
Cancer
Cancer therapies
Glioma
Hydrogen
Inflammation
Leukocyte migration
Macrophages
Matrix metalloproteinase
Matrix metalloproteinases
Na+/H + exchangers
Na+/H+-exchanging ATPase
Oxidative stress
Tumors
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-c3534-7eb7ec7566565fc7c8765995cdde92c9c2dbd16606665a942a6d918e53ba32f83
cites cdi_FETCH-LOGICAL-c3534-7eb7ec7566565fc7c8765995cdde92c9c2dbd16606665a942a6d918e53ba32f83
container_end_page 665
container_issue 2
container_start_page 658
container_title Journal of cellular physiology
container_volume 235
creator Tamtaji, Omid Reza
Mirzaei, Hamed
Shamshirian, Amir
Shamshirian, Danial
Behnam, Mohammad
Asemi, Zatollah
description Glioma is the oneof the most prevalent primarybrain tumors. There is a variety of oxidative stresses, inflammatory pathways, apoptosis signaling, and Na+/H + exchangers (NHEs) involved in the pathophysiology of glioma. Previous studies have indicated a relationship between NHEs and some molecular pathways in glioma. NHEs, including NHE1, NHE5, and NHE9 affect apoptosis, tumor‐associated macrophage inflammatory pathways, matrix metalloproteinases, cancer‐cell growth, invasion, and migration of glioma. Also, inhibition of NHEs contributes to increased survival in animal models of glioma. Limited studies, however, have assessed the relationship between NHEs and molecular pathways in glioma. This review summarizes current knowledge and evidence regarding the relationship between NHEs and glioma, and the mechanisms involved. Previous studies have indicated a relationship between Na+/H + exchangers (NHEs) and some molecular pathways in glioma. NHEs, including NHE1, NHE5, and NHE9 affect apoptosis, tumor‐associated macrophage inflammatory pathways, matrix metalloproteinases, cancer‐cell growth, invasion, and migration of glioma. Also, inhibition of NHEs contributes to increased survival in the animal models of glioma.
doi_str_mv 10.1002/jcp.29014
format article
fullrecord <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2250638101</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2317568682</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3534-7eb7ec7566565fc7c8765995cdde92c9c2dbd16606665a942a6d918e53ba32f83</originalsourceid><addsrcrecordid>eNp10E1PAjEQBuDGaATRg3_ANPGiIQv92Ha33ghR0RD0gOem2x1gybKL7RLk31sFPZh4msM8eTPzInRJSY8SwvpLu-4xRWh8hNqUqCSKpWDHqB12NFIipi105v2SEKIU56eoxSkTJI7jNhpMYIsbB1XucVHheVnUK4OtqSw43CzAmfXuDk-Nm0NTVHM8Md3-CHcxfNiFqebg_Dk6mZnSw8VhdtDbw_10OIrGL49Pw8E4slzwOEogS8AmQkohxcwmNk2kUErYPAfFrLIsz3IqJZFBGBUzI3NFUxA8M5zNUt5BN_vctavfN-AbvSq8hbI0FdQbr1l4SfKUEhro9R-6rDeuCtdpxmm4IZUpC-p2r6yrvXcw02tXrIzbaUr0V6869Kq_ew326pC4yVaQ_8qfIgPo78G2KGH3f5J-Hr7uIz8BZLB-Yg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2317568682</pqid></control><display><type>article</type><title>New trends in glioma cancer therapy: Targeting Na+/H + exchangers</title><source>Wiley-Blackwell Read &amp; Publish Collection</source><creator>Tamtaji, Omid Reza ; Mirzaei, Hamed ; Shamshirian, Amir ; Shamshirian, Danial ; Behnam, Mohammad ; Asemi, Zatollah</creator><creatorcontrib>Tamtaji, Omid Reza ; Mirzaei, Hamed ; Shamshirian, Amir ; Shamshirian, Danial ; Behnam, Mohammad ; Asemi, Zatollah</creatorcontrib><description>Glioma is the oneof the most prevalent primarybrain tumors. There is a variety of oxidative stresses, inflammatory pathways, apoptosis signaling, and Na+/H + exchangers (NHEs) involved in the pathophysiology of glioma. Previous studies have indicated a relationship between NHEs and some molecular pathways in glioma. NHEs, including NHE1, NHE5, and NHE9 affect apoptosis, tumor‐associated macrophage inflammatory pathways, matrix metalloproteinases, cancer‐cell growth, invasion, and migration of glioma. Also, inhibition of NHEs contributes to increased survival in animal models of glioma. Limited studies, however, have assessed the relationship between NHEs and molecular pathways in glioma. This review summarizes current knowledge and evidence regarding the relationship between NHEs and glioma, and the mechanisms involved. Previous studies have indicated a relationship between Na+/H + exchangers (NHEs) and some molecular pathways in glioma. NHEs, including NHE1, NHE5, and NHE9 affect apoptosis, tumor‐associated macrophage inflammatory pathways, matrix metalloproteinases, cancer‐cell growth, invasion, and migration of glioma. Also, inhibition of NHEs contributes to increased survival in the animal models of glioma.</description><identifier>ISSN: 0021-9541</identifier><identifier>EISSN: 1097-4652</identifier><identifier>DOI: 10.1002/jcp.29014</identifier><identifier>PMID: 31250444</identifier><language>eng</language><publisher>United States: Wiley Subscription Services, Inc</publisher><subject>Animal models ; Apoptosis ; Brain tumors ; Cancer ; Cancer therapies ; Glioma ; Hydrogen ; Inflammation ; Leukocyte migration ; Macrophages ; Matrix metalloproteinase ; Matrix metalloproteinases ; Na+/H + exchangers ; Na+/H+-exchanging ATPase ; Oxidative stress ; Tumors</subject><ispartof>Journal of cellular physiology, 2020-02, Vol.235 (2), p.658-665</ispartof><rights>2019 Wiley Periodicals, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3534-7eb7ec7566565fc7c8765995cdde92c9c2dbd16606665a942a6d918e53ba32f83</citedby><cites>FETCH-LOGICAL-c3534-7eb7ec7566565fc7c8765995cdde92c9c2dbd16606665a942a6d918e53ba32f83</cites><orcidid>0000-0003-2492-3996 ; 0000-0001-5265-4792 ; 0000-0002-9399-8281</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31250444$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tamtaji, Omid Reza</creatorcontrib><creatorcontrib>Mirzaei, Hamed</creatorcontrib><creatorcontrib>Shamshirian, Amir</creatorcontrib><creatorcontrib>Shamshirian, Danial</creatorcontrib><creatorcontrib>Behnam, Mohammad</creatorcontrib><creatorcontrib>Asemi, Zatollah</creatorcontrib><title>New trends in glioma cancer therapy: Targeting Na+/H + exchangers</title><title>Journal of cellular physiology</title><addtitle>J Cell Physiol</addtitle><description>Glioma is the oneof the most prevalent primarybrain tumors. There is a variety of oxidative stresses, inflammatory pathways, apoptosis signaling, and Na+/H + exchangers (NHEs) involved in the pathophysiology of glioma. Previous studies have indicated a relationship between NHEs and some molecular pathways in glioma. NHEs, including NHE1, NHE5, and NHE9 affect apoptosis, tumor‐associated macrophage inflammatory pathways, matrix metalloproteinases, cancer‐cell growth, invasion, and migration of glioma. Also, inhibition of NHEs contributes to increased survival in animal models of glioma. Limited studies, however, have assessed the relationship between NHEs and molecular pathways in glioma. This review summarizes current knowledge and evidence regarding the relationship between NHEs and glioma, and the mechanisms involved. Previous studies have indicated a relationship between Na+/H + exchangers (NHEs) and some molecular pathways in glioma. NHEs, including NHE1, NHE5, and NHE9 affect apoptosis, tumor‐associated macrophage inflammatory pathways, matrix metalloproteinases, cancer‐cell growth, invasion, and migration of glioma. Also, inhibition of NHEs contributes to increased survival in the animal models of glioma.</description><subject>Animal models</subject><subject>Apoptosis</subject><subject>Brain tumors</subject><subject>Cancer</subject><subject>Cancer therapies</subject><subject>Glioma</subject><subject>Hydrogen</subject><subject>Inflammation</subject><subject>Leukocyte migration</subject><subject>Macrophages</subject><subject>Matrix metalloproteinase</subject><subject>Matrix metalloproteinases</subject><subject>Na+/H + exchangers</subject><subject>Na+/H+-exchanging ATPase</subject><subject>Oxidative stress</subject><subject>Tumors</subject><issn>0021-9541</issn><issn>1097-4652</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNp10E1PAjEQBuDGaATRg3_ANPGiIQv92Ha33ghR0RD0gOem2x1gybKL7RLk31sFPZh4msM8eTPzInRJSY8SwvpLu-4xRWh8hNqUqCSKpWDHqB12NFIipi105v2SEKIU56eoxSkTJI7jNhpMYIsbB1XucVHheVnUK4OtqSw43CzAmfXuDk-Nm0NTVHM8Md3-CHcxfNiFqebg_Dk6mZnSw8VhdtDbw_10OIrGL49Pw8E4slzwOEogS8AmQkohxcwmNk2kUErYPAfFrLIsz3IqJZFBGBUzI3NFUxA8M5zNUt5BN_vctavfN-AbvSq8hbI0FdQbr1l4SfKUEhro9R-6rDeuCtdpxmm4IZUpC-p2r6yrvXcw02tXrIzbaUr0V6869Kq_ew326pC4yVaQ_8qfIgPo78G2KGH3f5J-Hr7uIz8BZLB-Yg</recordid><startdate>202002</startdate><enddate>202002</enddate><creator>Tamtaji, Omid Reza</creator><creator>Mirzaei, Hamed</creator><creator>Shamshirian, Amir</creator><creator>Shamshirian, Danial</creator><creator>Behnam, Mohammad</creator><creator>Asemi, Zatollah</creator><general>Wiley Subscription Services, Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7U7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>K9.</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-2492-3996</orcidid><orcidid>https://orcid.org/0000-0001-5265-4792</orcidid><orcidid>https://orcid.org/0000-0002-9399-8281</orcidid></search><sort><creationdate>202002</creationdate><title>New trends in glioma cancer therapy: Targeting Na+/H + exchangers</title><author>Tamtaji, Omid Reza ; Mirzaei, Hamed ; Shamshirian, Amir ; Shamshirian, Danial ; Behnam, Mohammad ; Asemi, Zatollah</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3534-7eb7ec7566565fc7c8765995cdde92c9c2dbd16606665a942a6d918e53ba32f83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Animal models</topic><topic>Apoptosis</topic><topic>Brain tumors</topic><topic>Cancer</topic><topic>Cancer therapies</topic><topic>Glioma</topic><topic>Hydrogen</topic><topic>Inflammation</topic><topic>Leukocyte migration</topic><topic>Macrophages</topic><topic>Matrix metalloproteinase</topic><topic>Matrix metalloproteinases</topic><topic>Na+/H + exchangers</topic><topic>Na+/H+-exchanging ATPase</topic><topic>Oxidative stress</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tamtaji, Omid Reza</creatorcontrib><creatorcontrib>Mirzaei, Hamed</creatorcontrib><creatorcontrib>Shamshirian, Amir</creatorcontrib><creatorcontrib>Shamshirian, Danial</creatorcontrib><creatorcontrib>Behnam, Mohammad</creatorcontrib><creatorcontrib>Asemi, Zatollah</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of cellular physiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tamtaji, Omid Reza</au><au>Mirzaei, Hamed</au><au>Shamshirian, Amir</au><au>Shamshirian, Danial</au><au>Behnam, Mohammad</au><au>Asemi, Zatollah</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>New trends in glioma cancer therapy: Targeting Na+/H + exchangers</atitle><jtitle>Journal of cellular physiology</jtitle><addtitle>J Cell Physiol</addtitle><date>2020-02</date><risdate>2020</risdate><volume>235</volume><issue>2</issue><spage>658</spage><epage>665</epage><pages>658-665</pages><issn>0021-9541</issn><eissn>1097-4652</eissn><abstract>Glioma is the oneof the most prevalent primarybrain tumors. There is a variety of oxidative stresses, inflammatory pathways, apoptosis signaling, and Na+/H + exchangers (NHEs) involved in the pathophysiology of glioma. Previous studies have indicated a relationship between NHEs and some molecular pathways in glioma. NHEs, including NHE1, NHE5, and NHE9 affect apoptosis, tumor‐associated macrophage inflammatory pathways, matrix metalloproteinases, cancer‐cell growth, invasion, and migration of glioma. Also, inhibition of NHEs contributes to increased survival in animal models of glioma. Limited studies, however, have assessed the relationship between NHEs and molecular pathways in glioma. This review summarizes current knowledge and evidence regarding the relationship between NHEs and glioma, and the mechanisms involved. Previous studies have indicated a relationship between Na+/H + exchangers (NHEs) and some molecular pathways in glioma. NHEs, including NHE1, NHE5, and NHE9 affect apoptosis, tumor‐associated macrophage inflammatory pathways, matrix metalloproteinases, cancer‐cell growth, invasion, and migration of glioma. Also, inhibition of NHEs contributes to increased survival in the animal models of glioma.</abstract><cop>United States</cop><pub>Wiley Subscription Services, Inc</pub><pmid>31250444</pmid><doi>10.1002/jcp.29014</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0003-2492-3996</orcidid><orcidid>https://orcid.org/0000-0001-5265-4792</orcidid><orcidid>https://orcid.org/0000-0002-9399-8281</orcidid></addata></record>
fulltext fulltext
identifier ISSN: 0021-9541
ispartof Journal of cellular physiology, 2020-02, Vol.235 (2), p.658-665
issn 0021-9541
1097-4652
language eng
recordid cdi_proquest_miscellaneous_2250638101
source Wiley-Blackwell Read & Publish Collection
subjects Animal models
Apoptosis
Brain tumors
Cancer
Cancer therapies
Glioma
Hydrogen
Inflammation
Leukocyte migration
Macrophages
Matrix metalloproteinase
Matrix metalloproteinases
Na+/H + exchangers
Na+/H+-exchanging ATPase
Oxidative stress
Tumors
title New trends in glioma cancer therapy: Targeting Na+/H + exchangers
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-02T04%3A26%3A04IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=New%20trends%20in%20glioma%20cancer%20therapy:%20Targeting%20Na+/H%20+%20exchangers&rft.jtitle=Journal%20of%20cellular%20physiology&rft.au=Tamtaji,%20Omid%20Reza&rft.date=2020-02&rft.volume=235&rft.issue=2&rft.spage=658&rft.epage=665&rft.pages=658-665&rft.issn=0021-9541&rft.eissn=1097-4652&rft_id=info:doi/10.1002/jcp.29014&rft_dat=%3Cproquest_cross%3E2317568682%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c3534-7eb7ec7566565fc7c8765995cdde92c9c2dbd16606665a942a6d918e53ba32f83%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=2317568682&rft_id=info:pmid/31250444&rfr_iscdi=true