Ochrocephalamines B–D, Three Alkaloids from Oxytropis ochrocephala Bunge

Ochrocephalamines B–D (1–3), composed of fused quinolizidine and octahydroquinoline rings, were isolated from Oxytropis ochrocephala Bunge. Ochrocephalamine B (1) has a unique bridged tetracyclic ring skeleton fused with a lactam ring. The structures of 1–3 were elucidated using spectroscopic and co...

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Bibliographic Details
Published in:Organic letters 2019-07, Vol.21 (13), p.5051-5054
Main Authors: Zhou, Kang-Sheng, Yi, Ping, Yang, Tao, Tian, Wen, Yang, Fu-Mei, Lee, Kuo-Hsiung, Zhao, Bao-Yu, Wang, Yue-Hu, Tan, Cheng-Jian
Format: Article
Language:English
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Summary:Ochrocephalamines B–D (1–3), composed of fused quinolizidine and octahydroquinoline rings, were isolated from Oxytropis ochrocephala Bunge. Ochrocephalamine B (1) has a unique bridged tetracyclic ring skeleton fused with a lactam ring. The structures of 1–3 were elucidated using spectroscopic and computational approaches. Ochrocephalamine C (2) and D (3) demonstrated potent anti-HBV activities and are more potent against the secretion of HBeAg than that of HBsAg.
ISSN:1523-7060
1523-7052
DOI:10.1021/acs.orglett.9b01643