MAGIC versus MacDonald treatment regimens for gastric cancer: Trends and predictors of multimodal therapy for gastric cancer using the National Cancer Database

Multimodal therapy is beneficial in gastric cancer, however this practice is not universal. This study examines trends, identifies associative factors, and examines overall survival (OS) benefit from multimodal therapy in gastric cancer. Gastric cancer patients staged IB-III from 2005 to 2014, ident...

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Bibliographic Details
Published in:The American journal of surgery 2020-01, Vol.219 (1), p.129-135
Main Authors: Jayanathan, Mark, Erwin, Ryan P., Molacek, Nicholas, Fluck, Marcus, Hunsinger, Marie, Wild, Jeffrey, Arora, Tania K., Shabahang, Mohsen M., Franko, Jan, Blansfield, Joseph A.
Format: Article
Language:English
Subjects:
Adjuvant chemotherapy
Adolescent
Adult
Age
Aged
Antineoplastic Agents - therapeutic use
Cancer
Cancer therapies
Chemoradiotherapy
Chemoradiotherapy, Adjuvant
Chemotherapy
Combined Modality Therapy - trends
Databases, Factual
Decision making
Female
Gastrectomy
Gastric cancer
Humans
Identification methods
Male
Medicaid
Medicare
Middle Aged
Multimodal therapy
Neoadjuvant therapy
Patients
Preoperative Period
Retrospective Studies
Stomach Neoplasms - mortality
Stomach Neoplasms - therapy
Studies
Surgeons
Surgery
Survival
Survival Rate
Trends
Young Adult
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Summary:Multimodal therapy is beneficial in gastric cancer, however this practice is not universal. This study examines trends, identifies associative factors, and examines overall survival (OS) benefit from multimodal therapy in gastric cancer. Gastric cancer patients staged IB-III from 2005 to 2014, identified using the National Cancer Database, were categorized by treatment: surgery alone, perioperative chemotherapy, and adjuvant chemoradiation. Groups were analyzed to identify associative factors of perioperative therapy. We examined 9243 patients, with the majority receiving multimodal therapy (57%). The proportion of those receiving perioperative chemotherapy rose dramatically from 7.5% in 2006 to 46% in 2013. Academic center treatment was strongly associated with perioperative over adjuvant therapy (p 
ISSN:0002-9610
1879-1883
DOI:10.1016/j.amjsurg.2019.06.005