Prognostic and predictive significance of KIT protein expression and c‐kit gene mutation in canine cutaneous mast cell tumours: A consensus of the Oncology‐Pathology Working Group

One of the primary objectives of the Oncology‐Pathology Working Group (OPWG), a joint initiative of the Veterinary Cancer Society and the American College of Veterinary Pathologists, is for oncologists and pathologists to collaboratively generate consensus documents to standardize aspects of and pro...

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Bibliographic Details
Published in:Veterinary & comparative oncology 2019-12, Vol.17 (4), p.451-455
Main Authors: Thamm, Douglas H., Avery, Anne C., Berlato, Davide, Bulman‐Fleming, Julie, Clifford, Craig A., Hershey, A. Elizabeth, Intile, Joanne L., Jones, Pamela D., Kamstock, Debra A., Liptak, Julius M., Pavuk, Alana, Peauroi, John, Powell, Roger, Rissetto, Kerry, Valli, Victor E. O., Webster, Joshua D.
Format: Article
Language:English
Subjects:
Animals
cancer
dog
Dog Diseases - metabolism
Dogs
Gene Expression Regulation, Neoplastic - physiology
immunohistochemistry
kinase
Mastocytoma - metabolism
Mastocytoma - veterinary
Mutation
Proto-Oncogene Proteins c-kit - genetics
Proto-Oncogene Proteins c-kit - metabolism
Skin Neoplasms - metabolism
Skin Neoplasms - veterinary
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Summary:One of the primary objectives of the Oncology‐Pathology Working Group (OPWG), a joint initiative of the Veterinary Cancer Society and the American College of Veterinary Pathologists, is for oncologists and pathologists to collaboratively generate consensus documents to standardize aspects of and provide guidelines for oncologic pathology. Consensus is established through critical review of peer‐reviewed literature relevant to a subgroup's particular focus. Subsequent acceptance and approval of the document by the OPWG membership at large establishes consensus. The intent of this publication is to help educate practitioners and pathologists on the value of diagnostics related to the KIT receptor tyrosine kinase for canine cutaneous mast cell tumours and to provide a guide for the use of these tests in veterinary medicine. This document represents the opinions of the OPWG and the authors and does not constitute a formal endorsement by the American College of Veterinary Pathologists or the Veterinary Cancer Society.
ISSN:1476-5810
1476-5829
DOI:10.1111/vco.12518