Acid Suppression Therapy and Symptom Improvement (or Lack Thereof) in Children

Acid suppression therapy, in the form of histamine H2-receptor antagonists (H2RAs) and proton pump inhibitors (PPIs), is a common treatment in pediatrics for management of gastroesophageal reflux (GER). Symptoms commonly associated with GER in younger children include frequent emesis, back arching,...

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Published in:Pediatrics (Evanston) 2019-07, Vol.144 (1), p.1
Main Authors: Boruta, Mary, Boruta, Richard, Li, Jennifer
Format: Article
Language:English
Subjects:
Acids
Antacids
Child
Child, Preschool
Children
Gastroesophageal Reflux
Histamine
Humans
Infants
Proton pump inhibitors
Regurgitation
Secondary Prevention
Treatment Outcome
Vomiting
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Boruta, Richard
Li, Jennifer
description Acid suppression therapy, in the form of histamine H2-receptor antagonists (H2RAs) and proton pump inhibitors (PPIs), is a common treatment in pediatrics for management of gastroesophageal reflux (GER). Symptoms commonly associated with GER in younger children include frequent emesis, back arching, fussiness, and discomfort. GER symptoms are reported in 10.3% of all children, with symptoms even more commonly noted in individuals
doi_str_mv 10.1542/peds.2019-0909
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Symptoms commonly associated with GER in younger children include frequent emesis, back arching, fussiness, and discomfort. GER symptoms are reported in 10.3% of all children, with symptoms even more commonly noted in individuals &lt;2 years old.1 At 4 months of age, 67% of children have daily regurgitation. Parents report a perceived problem with GER in 23% of 6-month-old infants.2 This high rate of concern results in GER being a common complaint in outpatient and inpatient settings. Combined with the ready availability of acid suppression therapy, this has led to increased prescribing of both H2RAs and PPIs in both infants and older children.3,4 Acid suppression therapy has been previously viewed as benign; however, recent research has revealed that these medications may carry risk.</description><identifier>ISSN: 0031-4005</identifier><identifier>EISSN: 1098-4275</identifier><identifier>DOI: 10.1542/peds.2019-0909</identifier><identifier>PMID: 31175147</identifier><language>eng</language><publisher>United States: American Academy of Pediatrics</publisher><subject>Acids ; Antacids ; Child ; Child, Preschool ; Children ; Gastroesophageal Reflux ; Histamine ; Humans ; Infants ; Proton pump inhibitors ; Regurgitation ; Secondary Prevention ; Treatment Outcome ; Vomiting</subject><ispartof>Pediatrics (Evanston), 2019-07, Vol.144 (1), p.1</ispartof><rights>Copyright American Academy of Pediatrics Jul 2019</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c363t-24c942f78f155d9ab0a9c5ac1676eb90cee0790a2b07bc8d8dde3dc8087960273</citedby><cites>FETCH-LOGICAL-c363t-24c942f78f155d9ab0a9c5ac1676eb90cee0790a2b07bc8d8dde3dc8087960273</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31175147$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Boruta, Mary</creatorcontrib><creatorcontrib>Boruta, Richard</creatorcontrib><creatorcontrib>Li, Jennifer</creatorcontrib><title>Acid Suppression Therapy and Symptom Improvement (or Lack Thereof) in Children</title><title>Pediatrics (Evanston)</title><addtitle>Pediatrics</addtitle><description>Acid suppression therapy, in the form of histamine H2-receptor antagonists (H2RAs) and proton pump inhibitors (PPIs), is a common treatment in pediatrics for management of gastroesophageal reflux (GER). 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subjects Acids
Antacids
Child
Child, Preschool
Children
Gastroesophageal Reflux
Histamine
Humans
Infants
Proton pump inhibitors
Regurgitation
Secondary Prevention
Treatment Outcome
Vomiting
title Acid Suppression Therapy and Symptom Improvement (or Lack Thereof) in Children
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