Exosomes from adipose-derived stem cells alleviate neural injury caused by microglia activation via suppressing NF-kB and MAPK pathway

• Published in: Journal of neuroimmunology 2019-09, Vol.334, p.576996-576996, Article 576996
• Main Authors: Feng, Nianhua, Jia, Yanjun, Huang, Xiaoxi
• Format: Article
• Language: English
• Subjects: Adipose-derived stem cells; Exosomes; Inflammation; Microglia; Neural injury
• ISSN: 0165-5728; 1872-8421
• DOI: 10.1016/j.jneuroim.2019.576996

Activation of microglia cells play critical role in neuroinflammation after brain injury. Exosomes from adipose-derived stem cells (ADSC) possess immunoregulation effect similar with ADSC. We hypothesized that ADSC derived exosomes (ADSC-exosomes) could inhibit the activation of microglia cells and prevent neuroinflammation. We found that ADSC-exosomes could inhibit the activation of microglia cells by suppressing NF-kB and MAPK pathway. Production of inflammatory factors in lipopolysaccharide-stimulated microglia cells decreased significantly when pretreated with ADSC-exosomes. Furthermore, ADSC-exosomes could decrease the cytotoxicity of activated microglia. These results revealed that ADSC-exosomes might be a promising strategy for the therapy of neural injury. [Display omitted] •Activated microglia cells secreted inflammatory factors and caused neural injury.•ADSC-exosomes could inhibit the activation of microglia cells by suppressing NF-kB and MAPK pathway.•ADSC-exosomes pretreatment could protect neural cells from injury caused by LPS stimulated-microglia cells.