p-Coumaric Acid Attenuates Lipopolysaccharide-Induced Lung Inflammation in Rats by Scavenging ROS Production: an In Vivo and In Vitro Study

Lipopolysaccharide (LPS), known as lipoglycans and endotoxins found in the cell wall of some type of Gram-negative bacteria, causes acute lung inflammation (ALI). p-Coumaric acid (p-CA) possesses anti-inflammatory and anti-oxidative activities. The main purpose of our research was to explore the eff...

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Bibliographic Details
Published in:Inflammation 2019-12, Vol.42 (6), p.1939-1950
Main Authors: Kheiry, Maryam, Dianat, Mahin, Badavi, Mohammad, Mard, Seyyed Ali, Bayati, Vahid
Format: Article
Language:English
Subjects:
A549 Cells
Animals
Anti-Inflammatory Agents - pharmacology
Antioxidants
Antioxidants - pharmacology
Biomedical and Life Sciences
Biomedicine
Cell walls
Coumaric acid
Endotoxins
Gene expression
Gram-negative bacteria
Humans
Immunology
Inflammation
Interleukin 6
Internal Medicine
Lipopolysaccharides
Lungs
NRF2 protein
Original Article
Oxidative stress
Oxidative Stress - drug effects
p-Coumaric acid
Pathology
Pharmacology/Toxicology
Pneumonia - drug therapy
Pneumonia - prevention & control
Propionates - pharmacology
Rats
Reactive Oxygen Species - metabolism
Rheumatology
Tumor necrosis factor-α
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Summary:Lipopolysaccharide (LPS), known as lipoglycans and endotoxins found in the cell wall of some type of Gram-negative bacteria, causes acute lung inflammation (ALI). p-Coumaric acid (p-CA) possesses anti-inflammatory and anti-oxidative activities. The main purpose of our research was to explore the effect of p-CA on LPS-induced inflammation. In part I, 32 rats were divided into four groups: Control, LPS (5 mg/kg), p-CA (100 mg/kg), and LPS + p-CA to investigate acute lung inflammation caused by LPS. In part II, the effect of LPS-stimulated inflammatory response on A549 cells was investigated. The dosage of LPS and p-CA which used in this part was 1 μg/ml and 20 mM, respectively. ALI rats showed an elevation in antioxidant activity, TNF-alpha, IL-6, MDA, inflammatory parameters, and Nrf2 gene expression. Although pre-treatment with p-CA could return these changes approximately to normal condition in all two-part studies ( in vivo and in vitro ). The results of in vivo and in vitro study showed that LPS induced lung inflammation. Pre-treatment with p-CA causes modulating of oxidative stress in inflammatory condition in lung injury and A549 cell.
ISSN:0360-3997
1573-2576
DOI:10.1007/s10753-019-01054-6