Accuracy of ITK-SNAP software for 3D analysis of a non-regular topography structure

• Published in: Oral radiology 2020-04, Vol.36 (2), p.183-189
• Main Authors: Gomes, Amanda Farias, Brasil, Danieli Moura, Silva, Amaro Ilídio Vespasiano, Freitas, Deborah Queiroz, Haiter-Neto, Francisco, Groppo, Francisco Carlos
• Format: Article
• Language: English
• Subjects: Computed tomography; Computer programs; Cone-Beam Computed Tomography; Dentistry; Imaging; Imaging, Three-Dimensional; Itk protein; Mathematical models; Medicine; Oral and Maxillofacial Surgery; Original Article; Phantoms, Imaging; Radiology; Regression analysis; Reproducibility of Results; Rubber; Segmentation; Software
• ISSN: 0911-6028; 1613-9674
• DOI: 10.1007/s11282-019-00397-y

Objectives To evaluate the accuracy of ITK-SNAP software for measuring volumes of a non-regular shape structure, using cone beam computed tomography (CBCT) scans, besides for developing a mathematical model to correct the software measurement error in case it existed. Methods A phantom made by moulding a rubber duck’s head was filled with total (38,000 mm 3 ) and partial volumes of water (7000 mm 3 , 14,000 mm 3 , 21,000 mm 3 , 28,000 mm 3 and 35,000 mm 3 ), which constituted the gold standards. The sound phantom and the phantom filled with different volumes of water were scanned in a Picasso Trio CBCT unit set at 80 kVp, 3.7 mA, 0.2 mm 3 voxel and 12 × 8.5 cm field of view. Semi-automatic segmentation was performed with ITK-SNAP 3.0 software by two trained oral radiologists. Linear regression analyzed the relation between ITK-SNAP calculated volumes and the gold standard. Intraclass correlation coefficient was applied to analyze the reproducibility of the method. Significance level was set at 5%. Results Linear regression analysis showed a significant relationship between ITK-SNAP volumes and the gold standard ( F  = 22,537.3, p