Management of cT4 Prostate Cancer

While radiotherapy with androgen deprivation therapy is the current standard of care for the treatment of stage cT4 prostate cancer (PC), surgery may also be an appropriate option in selected patients as part of a multimodal approach. The role and the sequence with which to optimize therapy combinat...

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Bibliographic Details
Published in:European urology focus 2020-03, Vol.6 (2), p.221-226
Main Authors: Ranasinghe, Weranja K.B., Reichard, Chad A., Bathala, Tharakeswara, Chapin, Brian F.
Format: Article
Language:English
Subjects:
Combined Modality Therapy
cT4
Humans
Locally advanced prostate cancer
Male
Management
Neoplasm Staging
Prostate cancer
Prostatic Neoplasms - pathology
Prostatic Neoplasms - therapy
Treatment
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Summary:While radiotherapy with androgen deprivation therapy is the current standard of care for the treatment of stage cT4 prostate cancer (PC), surgery may also be an appropriate option in selected patients as part of a multimodal approach. The role and the sequence with which to optimize therapy combinations in this setting are still unknown. This mini review summarizes the current evidence for management of cT4 PC. This mini review examines current evidence for the treatment options for locally advanced prostate cancer. The role of surgery in these patients can be considered as part of a combination treatment strategy along with other modalities such as radiotherapy and hormone therapy. There is growing evidence of survival benefits from local therapy for cT4 prostate cancer, with radiotherapy and androgen deprivation therapy continuing to be the mainstays of treatment. Surgery may be considered as part of a multimodal treatment strategy with acceptable morbidity.
ISSN:2405-4569
2405-4569
DOI:10.1016/j.euf.2019.06.012