Six-minute walk test before and after large-volume paracentesis in cirrhotic patients with refractory ascites: A pilot study

Functional impairment is common among cirrhotic patients with refractory ascites, and improvement in functional impairment is an expected issue after paracentesis. The six-minute walk test (6MWT) is considered an objective test for functional activity. No published data have evaluated the 6MWT among...

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Bibliographic Details
Published in:Arab journal of gastroenterology 2019-06, Vol.20 (2), p.81-85
Main Authors: Makhlouf, Nahed A., Mahran, Zainab Gaber, Sadek, Samiaa Hamdy, Magdy, Doaa M., Makhlouf, Hoda A.
Format: Article
Language:English
Subjects:
6MWT
Ascites - etiology
Ascites - physiopathology
Ascites - surgery
Cirrhosis
Dyspnea - etiology
Exercise Tolerance
Female
Forced Expiratory Volume
Humans
Liver Cirrhosis - complications
Male
Middle Aged
Oxygen - blood
Paracentesis
Pilot Projects
Prospective Studies
Pulmonary Diffusing Capacity
Serum Albumin - metabolism
Vital Capacity
Walk Test
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Summary:Functional impairment is common among cirrhotic patients with refractory ascites, and improvement in functional impairment is an expected issue after paracentesis. The six-minute walk test (6MWT) is considered an objective test for functional activity. No published data have evaluated the 6MWT among cirrhotic patients with refractory ascites before and after large-volume paracentesis. The research aim was to assess the feasibility of performing the 6MWT among cirrhotic patients who had refractory ascites before and after large-volume paracentesis. Thirty-one cirrhotic inpatients with refractory ascites were subjected to pulmonary function tests (forced expiratory volume in one second [FEV1], forced vital capacity [FVC], FEV1/FVC) and diffusion lung capacity for carbon monoxide (DLCO) before and 48 h after therapeutic large-volume paracentesis. Dyspnoea as assessed by the Borg scale and functional capacity as assessed by the 6MWT were also evaluated. Prior to paracentesis, the mean values of FVC and FEV1 were lower than the predicted values, and a significant increase was observed after paracentesis. There was improvement in the mean DLCO values after paracentesis (P 
ISSN:1687-1979
2090-2387
DOI:10.1016/j.ajg.2019.05.009