Soluble guanylate cyclase isoenzymes: The expression of α1, α2, β1, and β2 subunits in the benign and malignant breast tumors

Soluble guanylate cyclase (sGC) encompasses α and β subunits. This study examined the expression of α1, α2, β1, and β2 subunits in the malignant and benign breast tumors using the Western blot  analysis. Both benign and malignant tumors showed a significantly higher expression of the α1 subunit in c...

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Bibliographic Details
Published in:Journal of cellular physiology 2020-02, Vol.235 (2), p.1358-1365
Main Authors: Mohammadoo‐Khorasani, Milad, Karami Tehrani, Fatemeh, Atri, Morteza
Format: Article
Language:English
Subjects:
Anticancer properties
Antitumor activity
Benign
Breast cancer
ErbB-2 protein
Guanylate cyclase
Isoenzymes
sGC subunits
soluble guanylyl cyclase expression
Tumors
α1, α2
β1, β2
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Summary:Soluble guanylate cyclase (sGC) encompasses α and β subunits. This study examined the expression of α1, α2, β1, and β2 subunits in the malignant and benign breast tumors using the Western blot  analysis. Both benign and malignant tumors showed a significantly higher expression of the α1 subunit in comparison with normal tissues (p 
ISSN:0021-9541
1097-4652
DOI:10.1002/jcp.29054