Broken Rice as a Potential Functional Ingredient with Inhibitory Activity of Renin and Angiotensin-Converting Enzyme(ACE)

The aim of this work was to evaluate the ability of broken rice, an underutilized industrial by-product, as a potential functional and health promoting ingredient. With this purpose, the ability to inhibit the angiotensin converting enzyme and renin of a rice protein hydrolyzate (RPH) obtained from...

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Bibliographic Details
Published in:Plant foods for human nutrition (Dordrecht) 2019-09, Vol.74 (3), p.405-413
Main Authors: Pinciroli, María, Aphalo, Paula, Nardo, Agustina E., Añón, María C., Quiroga, Alejandra V.
Format: Article
Language:English
Subjects:
Angiotensin
Biological properties
Byproducts
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
Conversion
Ecology
Enzymes
Food Science
High performance liquid chromatography
Liquid chromatography
Nutrition
Original Paper
Peptides
Peptidyl-dipeptidase A
Plant Physiology
Protein purification
Proteins
Renin
Rice
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Summary:The aim of this work was to evaluate the ability of broken rice, an underutilized industrial by-product, as a potential functional and health promoting ingredient. With this purpose, the ability to inhibit the angiotensin converting enzyme and renin of a rice protein hydrolyzate (RPH) obtained from a high-protein variety of broken rice (var. Nutriar FCAyF) was analyzed (IC 50  = 0.87 and 2.7 mg/mL, respectively). RPH was separated by gel permeation chromatography and in a second purification step by RP-HPLC. The sequence of antihypertensive peptides presented in two RP-HPLC fractions was analyzed. Peptides capable of interacting with the active sites of both enzymes were identified. In this study, we demonstrate that the hydrolysis treatment improves functional and biological properties of rice proteins. Protein preparations obtained from a by-product of rice industry, such as broken rice, are a promising ingredient with potentially good biological properties.
ISSN:0921-9668
1573-9104
DOI:10.1007/s11130-019-00754-6