Two new phthalide derivatives from the endophytic fungus Penicillium vulpinum isolated from Sophora tonkinensis

Two new phthalide derivatives, (-)-3-carboxypropyl-7-hydroxyphthalide (1) and (-)-3-carboxypropyl-7-hydroxyphthalide methyl ester (2), were isolated from the endophytic fungus Penicillium vulpinum isolated from the Chinese medicinal plant Sophora tonkinensis. Their structures were elucidated using s...

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Bibliographic Details
Published in:Natural product research 2021-02, Vol.35 (3), p.421-427
Main Authors: Qin, Yuyue, Liu, Xiaobo, Lin, Jing, Huang, Jingying, Jiang, Xiaofei, Mo, Tuxiang, Xu, Zhaolong, Li, Jun, Yang, Ruiyun
Format: Article
Language:English
Subjects:
Anti-Bacterial Agents - chemistry
Anti-Bacterial Agents - pharmacology
Bacillus subtilis - drug effects
Benzofurans - chemistry
Benzofurans - pharmacology
Derivatives
Drug Evaluation, Preclinical
Endophytes
Endophytes - chemistry
endophytic fungus
Enterobacter - drug effects
Fungi
Herbal medicine
Magnetic Resonance Spectroscopy
Medicinal plants
Microbial Sensitivity Tests
Minimum inhibitory concentration
Molecular Structure
NMR
Nuclear magnetic resonance
Penicillium
Penicillium - chemistry
Penicillium - isolation & purification
Penicillium sp
phthalide
Plants, Medicinal - microbiology
Shigella dysenteriae - drug effects
Sophora
Sophora - microbiology
Sophora tonkinensis
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Summary:Two new phthalide derivatives, (-)-3-carboxypropyl-7-hydroxyphthalide (1) and (-)-3-carboxypropyl-7-hydroxyphthalide methyl ester (2), were isolated from the endophytic fungus Penicillium vulpinum isolated from the Chinese medicinal plant Sophora tonkinensis. Their structures were elucidated using spectroscopic methods, mainly on 1D and 2D NMR. Compound 1 exhibited medium antibacterial activities against Bacillus subtilis, Shigella dysenteriae and Enterobacter areogenes with MIC values of 12.5-25 μg/mL, and 2 showed a medium inhibition to E. areogenes with MIC value of 12.5 μg/mL.
ISSN:1478-6419
1478-6427
DOI:10.1080/14786419.2019.1636237