Antibiotic hypersensitivity in MRSA induced by special protein aggregates

Emergence of multidrug-resistant bacteria is a major global concern. According to WHO, methicillin-resistant Staphylococcus aureus (MRSA) is a threatening pathogen resistant to a wide spectrum of antibiotics. Herein, to overcome drug resistance in MRSA, we successfully integrated traditional antibac...

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Bibliographic Details
Published in:International journal of biological macromolecules 2019-09, Vol.137, p.528-536
Main Authors: Tafvizizavareh, Shima, Shariati, Parvin, Sharifirad, Atefeh, Maleki, Behnam, Aliakbari, Farhang, Christiansen, Guanna, Morshedi, Dina
Format: Article
Language:English
Subjects:
Animals
Anti-Bacterial Agents - pharmacology
Antibiotic hypersensitivity
Drug Resistance, Multiple, Bacterial - drug effects
Drug Synergism
Methicillin-Resistant Staphylococcus aureus - drug effects
Microbial Sensitivity Tests
Microbial Viability - drug effects
Multidrug-resistant bacteria
Muramidase - chemistry
Muramidase - pharmacology
Oxacillin
Oxacillin - pharmacology
Protein Aggregates
Staphylococcus aureus
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Summary:Emergence of multidrug-resistant bacteria is a major global concern. According to WHO, methicillin-resistant Staphylococcus aureus (MRSA) is a threatening pathogen resistant to a wide spectrum of antibiotics. Herein, to overcome drug resistance in MRSA, we successfully integrated traditional antibacterial methods but with a novel trick that included use of hen egg-white lysozyme's special aggregates generated by fibrillization. The minimum inhibitory concentration of oxacillin (Ox) for MRSA declined from 600 μM to
ISSN:0141-8130
1879-0003
DOI:10.1016/j.ijbiomac.2019.07.001