Scoring Systems and Postoperative Outcomes in Pediatric Liver Transplantation

• Published in: Transplantation proceedings 2019-09, Vol.51 (7), p.2430-2433
• Main Authors: Ferah, Oya, Akbulut, Akın, Açık, Mehmet Eren, Gökkaya, Zafer, Acar, Umut, Yenidünya, Özlem, Yentür, Ercüment, Tokat, Yaman
• Format: Article
• Language: English
• Subjects: Acute Kidney Injury - etiology; Acute Kidney Injury - mortality; Child; End Stage Liver Disease - mortality; End Stage Liver Disease - surgery; Female; Hospital Mortality; Humans; Length of Stay - statistics & numerical data; Liver Transplantation - methods; Liver Transplantation - mortality; Male; Postoperative Complications - etiology; Postoperative Complications - mortality; Postoperative Period; Reference Values; Respiration, Artificial - statistics & numerical data; Retrospective Studies; Risk Assessment - methods; ROC Curve; Severity of Illness Index; Treatment Outcome
• ISSN: 0041-1345; 1873-2623
• DOI: 10.1016/j.transproceed.2019.01.174

The aim of this study is to investigate the effects of risk scores (Pediatric End-stage Liver Disease [PELD], Child-Turcotte-Pugh [CTP], and Pediatric Risk of Mortality [PRISM-III]) of pediatric liver transplant patients on the postoperative period. Seven cadaveric and 45 living donors, totaling 52 pediatric liver transplantation (LT) patients, were reviewed retrospectively. PELD and CTP scores were calculated based on data at hospital admission. PRISM-III score was calculated from data during the first 24 hours of intensive care unit (ICU) admission. Hospital length of stay (LOS), ICU LOS, patients who developed acute kidney injury (AKI), requirement for inotropic-vasopressor therapy, hospital mortality, long-term mortality, duration of mechanical ventilation, metabolic disease, and demographic features were documented.For CTP score, class C was defined as high, and A and B as low. Cutoff values of PELD and PRISM-III scores were detected by using receiver operating characteristic curves. According to these cutoff values, patients were divided into 2 groups as high and low for each score. Documented data was analyzed and compared in groups for each score. Hospital LOS was significantly longer in the high-PELD (P = .01) and high-CTP (P = .01) groups. ICU LOS was significantly longer in the high-PRISM-III group (P = .01). Requirement for inotropic-vasopressor therapy was significantly higher in the high-PELD (P = .04) and high-CTP (P = .04) groups. Hemodynamic instability and long hospital LOS can be expected in pediatric post-LT patients with high PELD or CTP scores; there is also the risk that AKI maybe higher for high-PELD score patients. Unexpectedly, the PRISM-III score did not have any correlation with the severity of physiological condition and mortality.