Predictors of Early Extubation after Patent Ductus Arteriosus Ligation among Infants Born Extremely Preterm Dependent on Mechanical Ventilation

We conducted a retrospective study of 166 ventilator-dependent neonates born extremely preterm in whom patent ductus arteriosus was surgically ligated and evaluated the association of preoperative characteristics and time-to-successful postoperative extubation. Larger patent ductus arteriosus diamet...

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Bibliographic Details
Published in:The Journal of pediatrics 2019-11, Vol.214, p.222-226.e3
Main Authors: Krishnappa, Srinath, Shah, Prakesh S., Jain, Amish, Resende, Maura H.F., McNamara, Patrick J., Weisz, Dany E.
Format: Article
Language:English
Subjects:
Airway Extubation - methods
Cardiac Surgical Procedures - methods
ductal diameter
ductal shunt volume
Ductus Arteriosus, Patent - diagnosis
Ductus Arteriosus, Patent - physiopathology
Ductus Arteriosus, Patent - surgery
Echocardiography
extremely low gestational age
Female
Follow-Up Studies
Gestational Age
Humans
Infant, Extremely Premature
Infant, Newborn
left ventricular dilatation
Ligation
Male
PDA
PDA surgery
peak systolic velocity
Postoperative Care - methods
pressure gradient
Prognosis
Respiration, Artificial - methods
Retrospective Studies
successful extubation
Systole
Time Factors
Ventricular Function, Left - physiology
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Description
Summary:We conducted a retrospective study of 166 ventilator-dependent neonates born extremely preterm in whom patent ductus arteriosus was surgically ligated and evaluated the association of preoperative characteristics and time-to-successful postoperative extubation. Larger patent ductus arteriosus diameter ([>2.5 mm], adjusted hazard ratio 0.51, 95% CI 0.36-0.72) and left-ventricular dilatation (z score ≥2, adjusted hazard ratio 0.61, 95% CI 0.42-0.87) were associated with earlier extubation.
ISSN:0022-3476
1097-6833
DOI:10.1016/j.jpeds.2019.06.027