The coexpression of fibroblast activation protein (FAP) and basal-type markers (CK 5/6 and CD44) predicts prognosis in high-grade invasive urothelial carcinoma of the bladder

High-grade urothelial carcinoma (UC) of the bladder is a heterogeneous disease with dismal prognosis. Bladder tumors with basal phenotype are intrinsically aggressive, and morphological parameters that define disease staging remain main prognosticators. We intend to evaluate the role of cancer-assoc...

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Bibliographic Details
Published in:Human pathology 2019-09, Vol.91, p.61-68
Main Authors: Calvete, Julio, Larrinaga, Gorka, Errarte, Peio, Martín, Ana M., Dotor, Ana, Esquinas, Cristina, Nunes-Xavier, Caroline E., Pulido, Rafael, López, José I., Angulo, Javier C.
Format: Article
Language:English
Subjects:
Automation
Basal phenotype
Biomarkers
Bladder cancer
Bladder neoplasia
Cancer therapies
Cell adhesion & migration
Chemotherapy
Comorbidity
Extracellular matrix
Fibroblast activation protein
Fibroblasts
Hemoglobin
Lymphatic system
Medical prognosis
Metastasis
Mortality
Prognosis
Statistical analysis
Survival
Survival analysis
Transitional cell carcinoma
Tumor microenvironment
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Summary:High-grade urothelial carcinoma (UC) of the bladder is a heterogeneous disease with dismal prognosis. Bladder tumors with basal phenotype are intrinsically aggressive, and morphological parameters that define disease staging remain main prognosticators. We intend to evaluate the role of cancer-associated fibroblasts (CAFs) in the prognosis of bladder cancer and its association with basal and luminal phenotypes. Clinical and pathological parameters, including the immunohistochemical expression of fibroblast activation protein (FAP) and markers of basal (CK5/6, CD44) and luminal (CK20, GATA3) phenotypes, have been investigated in a series of 121 patients with UC of the bladder treated by radical cystectomy with lymph node dissection, and their implication in long-term cancer-specific survival has been evaluated. A cytoplasmic immunostaining of FAP in CAFs implies worse disease-specific survival (hazard ratio [HR] = 1.68; P = .048). FAP expression is associated with tumor staging (P 
ISSN:0046-8177
1532-8392
DOI:10.1016/j.humpath.2019.07.002