Timing of adjuvant radiation therapy and survival outcomes after surgical resection of intracranial non-small cell lung cancer metastases

• Published in: Clinical neurology and neurosurgery 2019-08, Vol.183, p.105389-105389, Article 105389
• Main Authors: Sheppard, John P., Prashant, Giyarpuram N., Chen, Cheng Hao Jacky, Peeters, Sophie, Lagman, Carlito, Ong, Vera, Udawatta, Methma, Duong, Courtney, Nguyen, Thien, Romiyo, Prasanth, Gaonkar, Bilwaj, Yong, William H., Kaprealian, Tania B., Tenn, Stephen, Lee, Percy, Yang, Isaac
• Format: Article
• Language: English
• Subjects: Adjuvants; Brain cancer; Cancer therapies; Chemotherapy; Invasiveness; Lung cancer; Lung metastases; Metastases; Metastasis; Neurology; Neuropathology; Neurosurgery; Non-small cell lung cancer; Non-small cell lung carcinoma; Oncology; Patients; Pneumonia; Radiation; Radiation therapy; Radiotherapy; Rehabilitation; Risk factors; Surgery; Surveillance; Survival; Wound healing
• ISSN: 0303-8467; 1872-6968
• DOI: 10.1016/j.clineuro.2019.105389

•Cerebral lung metastases may be treated by multiple radiation modalities.•Number of metastatic lesions did not reflect on overall survival.•Delayed adjuvant radiation was correlated with poorer overall survival. : To investigate if delay of adjuvant radiotherapy (ART) beyond 6 post-operative weeks affects survival outcomes in patients undergoing craniotomy or craniectomy for resection of non-small cell lung cancer (NSCLC) intracranial metastases. We performed a retrospective analysis of 28 patients undergoing resection of intracranial metastases and ART at our institution from 2001 to 2016. We assessed survival outcomes for patients who received delayed versus non-delayed ART, as well as associated risk factors. Among 28 patients, 8 (29%) had delayed ART beyond 6 post-operative weeks. Fifteen received stereotactic radiotherapy (SRT), 8 (29%) received whole brain radiotherapy (WBRT), and 5 (18%) received combination WBRT + SRT. There were no significant differences in ART modality or dosing, age, sex, number of intracranial metastases, primary metastasis volume, rates of chemotherapy, extracranial metastases, or post-operative functional scores between groups. Expected post-operative survival was shorter with delayed ART (7 months versus 28 months, P = 0.01). The most common reason for delayed ART was complicated post-operative course (n = 3.38%). Significant risk factors for delayed ART included non-routine discharge (P = 0.01) and additional invasive procedures between surgery and ART start date (P = 0.02). Our results suggest delayed ART in patients undergoing surgical resection of intracranial NSCLC metastases is associated with shorter overall survival. However, risk factors for delayed ART, including non-routine discharge and the need for additional invasive procedures, may have in themselves reflected poorer clinical courses that may have also contributed to the observed survival differences.