Increased eosinophils in adipose tissue of metabolic syndrome

Metabolic Syndrome (MetS) is a common global disorder that predisposes to both Type 2 diabetes mellitus (T2DM) and cardiovascular disease (ASCVD). Adipose tissue (AT) contributes significantly to increased inflammation and insulin resistance (IR) in MetS which appear to be the crucial underpinnings...

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Bibliographic Details
Published in:Journal of diabetes and its complications 2019-08, Vol.33 (8), p.535-538
Main Authors: Moussa, Karine, Gurung, Purnima, Adams-Huet, Beverley, Devaraj, Sridevi, Jialal, Ishwarlal
Format: Article
Language:English
Subjects:
Biomarkers
Blood tests
Body fat
Cardiovascular disease
Cholesterol
Diabetes
Diabetic retinopathy
Eosinophils
Fasting
Fatty acids
Fibrosis
Inflammation
Insulin resistance
Laboratories
Metabolic Syndrome
Patients
Stains & staining
Subcutaneous adipose tissue
Thyroid gland
Triglycerides
Variables
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Summary:Metabolic Syndrome (MetS) is a common global disorder that predisposes to both Type 2 diabetes mellitus (T2DM) and cardiovascular disease (ASCVD). Adipose tissue (AT) contributes significantly to increased inflammation and insulin resistance (IR) in MetS which appear to be the crucial underpinnings of MetS. Compared to macrophages and lymphocytes in human subcutaneous AT (SAT), there is sparse data on the role of other immune cells, especially eosinophils (EOS). In this study, we investigated the abundance of EOS in the SAT of 19 patients with MetS without diabetes, ASCVD, smoking or any inflammatory condition, and matched controls. SAT EOS were quantified by immunohistochemistry. Both circulating and SAT EOS were significantly increased 2-fold in MetS and correlated with each other. Circulating EOS correlated significantly with triglycerides (TG), high-sensitivity CRP, leptin, and IL-6. SAT EOS correlated significantly with plasma glucose, TG, FFA, adipose-IR, leptin, IL-6, endotoxin, chemerin and inversely with adiponectin. They also correlated with SAT markers of fibrosis: collagen and Sirius red staining of SAT. We make the novel and seminal observation that eosinophils are increased in SAT of MetS patients, and are associated with the pro-inflammatory state. Hence, in humans, they appear to contribute to the dysregulation of SAT biology in MetS.
ISSN:1056-8727
1873-460X
DOI:10.1016/j.jdiacomp.2019.05.010